Abstract
Antisera against several strains of acid-fast bacteria have been separated into their euglobulin, pseudoglobulin and albumin fractions. The globulin fractions have been found to possess the essential properties of bacteriotropic sera: thus they alter the bacterial surface properties, and, in quantitative correspondence, cause agglutination and phagocytosis; these several effects withstand washing of the sensitized bacteria; the effects are little if at all affected by inactivation of the antisera before fractionation; the combination of antibody and antigen is serologically specific. The conclusion is drawn that the contact of antigen with fresh homologous immune serum results in the deposit on the antigen surface of a substance or substances contained in the globulin fractions of the antiserum; as a consequence of this surface deposit leucocytes can spread upon and engulf the antigen.
Full Text
The Full Text of this article is available as a PDF (622.8 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Goebel W. F., Avery O. T. CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : I. THE SYNTHESIS OFp-AMINOPHENOL beta-GLUCOSIDE, p-AMINOPHENOL beta-GALACTOSIDE, AND THEIR COUPLING WITH SERUM GLOBULIN. J Exp Med. 1929 Sep 30;50(4):521–531. doi: 10.1084/jem.50.4.521. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Landsteiner K., van der Scheer J. SEROLOGICAL DIFFERENTIATION OF STERIC ISOMERS (ANTIGENS CONTAINING TARTARIC ACIDS) : SECOND PAPER. J Exp Med. 1929 Sep 30;50(4):407–417. doi: 10.1084/jem.50.4.407. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lucké B., McCutcheon M., Strumia M., Mudd S. ON THE MECHANISM OF OPSONIN AND BACTERIOTROPIN ACTION : II. CORRELATION BETWEEN CHANGES IN BACTERIAL SURFACE PROPERTIES AND IN PHAGOCYTOSIS CAUSED BY NORMAL AND IMMUNE SERA. J Exp Med. 1929 Apr 30;49(5):797–813. doi: 10.1084/jem.49.5.797. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McCutcheon M., Strumia M., Mudd S., Mudd E. B., Lucké B. ON THE MECHANISM OF OPSONIN AND BACTERIOTROPIN ACTION : III. THE DEVELOPMENT AND EFFECT OF THE ANTIBODIES FOUND IN EXPERIMENTAL TUBERCULOSIS OF RABBITS. J Exp Med. 1929 Apr 30;49(5):815–831. doi: 10.1084/jem.49.5.815. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mudd S., Lucké B., McCutcheon M., Strumia M. ON THE MECHANISM OF OPSONIN AND BACTERIOTROPIN ACTION : I. CORRELATION BETWEEN CHANGES IN BACTERIAL SURFACE PROPERTIES AND IN PHAGOCYTOSIS CAUSED BY SERA OF ANIMALS UNDER IMMUNIZATION. J Exp Med. 1929 Apr 30;49(5):779–795. doi: 10.1084/jem.49.5.779. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mudd S., Mudd E. B. ON THE MECHANISM OF THE SERUM SENSITIZATION OF ACID-FAST BACTERIA. J Exp Med. 1927 Jun 30;46(1):173–195. doi: 10.1084/jem.46.1.173. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mudd S., Mudd E. B. ON THE SURFACE COMPOSITION OF NORMAL AND SENSITIZED MAMMALIAN BLOOD CELLS. J Exp Med. 1926 Jan 1;43(1):127–142. doi: 10.1084/jem.43.1.127. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shibley G. S. STUDIES IN AGGLUTINATION : III. ON THE MECHANISM OF THE AGGLUTINATION OF BACTERIA BY SPECIFIC AGGLUTINATING SERUM. J Exp Med. 1926 Oct 31;44(5):667–681. doi: 10.1084/jem.44.5.667. [DOI] [PMC free article] [PubMed] [Google Scholar]