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The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1931 Jan 1;53(1):137–142. doi: 10.1084/jem.53.1.137

REINFORCEMENT OF CONVALESCENT ANTIPOLIOMYELITIC SERUM IN THE MONKEY

C P Rhoads 1
PMCID: PMC2131946  PMID: 19869823

Abstract

A comparison has been made of the neutralizing value of pooled convalescent monkey serum for the filtered virus of poliomyelitis, before and after a series of reinforcement injections of the same virus strain. The strength of the pooled convalescent serum is increased by the reinforcing procedure. The original monkey convalescent serum had a neutralization value much below that of a pooled human convalescent serum. By reinforcement the neutralization value of the monkey serum was brought approximately to that of the human serum. One sample of serum from a supposedly normal child of 8 years exhibited a neutralizing value approximately equal to that of a pooled human convalescent serum and the reinforced pooled monkey serum.

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  1. Stewart F. W., Rhoads C. P. INTRADERMAL VERSUS SUBCUTANEOUS IMMUNIZATION OF MONKEYS AGAINST POLIOMYELITIS. J Exp Med. 1929 May 31;49(6):959–973. doi: 10.1084/jem.49.6.959. [DOI] [PMC free article] [PubMed] [Google Scholar]

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