Abstract
The clinical picture and gross pathology of spontaneous and experimental "mad itch" have been described and the inciting agent has been shown to be a filtrable virus. It has been possible to prepare virucidal serum capable of neutralizing the virus. Fatal infections are regularly produced in rabbits when the virus is administered subcutaneously, intracerebrally, intravenously, intratesticularly, intraperitoneally, intranasally, or when it is dropped on a scarified area of skin. Its infectivity for other species by various routes is reported upon. The rabbit, guinea pig, white rat, white mouse, gray field mouse, cow, cat, duck, chicken, and hog are susceptible to experimental infection. The disease is not contagious under laboratory conditions and the virus is restricted in the animal body largely to the region of inoculation and the lung. The virus can be stored for relatively long periods in 50 per cent glycerol or in the dried state. A comparison of "mad itch" with pseudorabies leads to the tentative conclusion that the inciting agents of both are the same, although the strains of the two viruses that are under study possess readily demonstrable differences
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Selected References
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- Shope R. E. "MAD ITCH" OF CATTLE. Science. 1930 Nov 28;72(1874):559–559. doi: 10.1126/science.72.1874.559. [DOI] [PubMed] [Google Scholar]
- Swift H. F. PRESERVATION OF STOCK CULTURES OF BACTERIA BY FREEZING AND DRYING. J Exp Med. 1921 Jan 1;33(1):69–75. doi: 10.1084/jem.33.1.69. [DOI] [PMC free article] [PubMed] [Google Scholar]