Abstract
1. The horse, apparently itself unsusceptible to poliomyelitis, can be stimulated in certain cases but not all to the production of virucidal antibodies. 2. The virucidal potency of such immune serum can be raised to a point comparable to that of human convalescent serum and when concentrated and refined exhibits a four-fold increase in potency. 3. Such concentrates have proved effective in the prevention of paralysis in inoculated monkeys when given intraspinously before the onset of paralysis. 4. Treatment has been found more effective when therapeutic serums are given through the spinal route. 5. Pooled serum from "normal" adult donors has proved effective in neutralizing virus but its potency is approximately one-half that of convalescent serum.
Full Text
The Full Text of this article is available as a PDF (607.8 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Rhoads C. P. EXPERIMENTAL STUDY OF A HORSE ANTIPOLIOMYELITIC SERUM. J Exp Med. 1931 Jan 1;53(1):123–135. doi: 10.1084/jem.53.1.123. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stewart F. W., Haselbauer P. VIRUS NEUTRALIZATION EXPERIMENTS WITH ROSENOW'S AND PETTIT'S ANTIPOLIOMYELITIC SERA. J Exp Med. 1928 Aug 31;48(3):449–455. doi: 10.1084/jem.48.3.449. [DOI] [PMC free article] [PubMed] [Google Scholar]