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The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1931 Sep 30;54(4):493–498. doi: 10.1084/jem.54.4.493

THE EFFECT OF TESTICLE EXTRACT AND OF NORMAL SERUM ON A TRANSPLANTABLE EPITHELIAL TUMOR OF THE RABBIT

F Duran-Reynals 1
PMCID: PMC2132018  PMID: 19869935

Abstract

Extract of rat, rabbit or bull testicle prevents or retards the growth of a rabbit tumor when a mixture of the extract and a tumor cell suspension is inoculated intradermally. Similar mixtures, made with normal rabbit serum instead of testicle extract, give rise to tumors which grow with unusual rapidity. The results are the opposite of those obtained with pathogenic bacteria or filtrable viruses which are enhanced by testicle extract and generally inhibited by normal serum.

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Selected References

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