Abstract
1. Type-specific agglutination of Pneumococcus Types I, II and III has been demonstrated in antisera largely deprived of the carbohydrate antibody. 2. The type-specific agglutinogens in Pneumococcus I and II responsible for agglutination in such antisera are inactivated by heating in alkaline solution at 100°C. The specific carbohydrate remains unaltered under these conditions. 3. The relationship of the type-specific agglutinogen in Pneurmococcus I to the type-specific A substance has been discussed. 4. The possible application of these results to the standardization of therapeutic antisera by agglutinin titre has been discussed. 5. On the basis of the experiments recorded a tentative explanation is offered for the failure of Pneumococcus Type II to absorb the agglutinins from anti-B. friedlaenderi Type B serum.
Full Text
The Full Text of this article is available as a PDF (469.5 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Avery O. T., Heidelberger M., Goebel W. F. THE SOLUBLE SPECIFIC SUBSTANCE OF FRIEDLANDER'S BACILLUS : PAPER II. CHEMICAL AND IMMUNOLOGICAL RELATIONSHIPS OF PNEUMOCOCCUS TYPE II AND OF A STRAIN OF FRIEDLANDER'S BACILLUS. J Exp Med. 1925 Oct 31;42(5):709–725. doi: 10.1084/jem.42.5.709. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Enders J. F. A TYPE SPECIFIC SUBSTANCE DISTINCT FROM THE SPECIFIC CARBOHYDRATE IN PNEUMOCOCCUS TYPE I. J Exp Med. 1930 Jul 31;52(2):235–252. doi: 10.1084/jem.52.2.235. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Friedlander M., Sobotka H., Banzhaf E. J. THE PRECIPITIN REACTION OF ANTIPNEUMOCOCCUS SERA : II. THE RATIO OF PRECIPITIN TO PROTECTIVE ANTIBODY. J Exp Med. 1928 Jan 1;47(1):79–89. doi: 10.1084/jem.47.1.79. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Heidelberger M., Sia R. H., Kendall F. E. SPECIFIC PRECIPITATION AND MOUSE PROTECTION IN TYPE I ANTIPNEUMOCOCCUS SERA. J Exp Med. 1930 Sep 30;52(4):477–483. doi: 10.1084/jem.52.4.477. [DOI] [PMC free article] [PubMed] [Google Scholar]