Abstract
Evidence is here given that polysaccharides can be rendered antigenic by haptogenic adsorption upon a colloid carrier. The polysaccharides studied were those of B. anthracis, the meningococcus, Streptococcus viridans (Bargen), B. proteus, S. morgani, B. dysenteriae, both the Shiga and Hiss types, and the pneumococci. With the polysaccharide of Type III pneumococci, we have been unable in 6 weeks to produce any detectable protective antibodies, but we were able to produce anticarbohydrate antibodies. All the bacterial carbohydrates were non-antigenic alone when used in the doses indicated, though containing some nitrogen. Dextran, which was free from nitrogen was also rendered antigenic by the adsorption method.
Full Text
The Full Text of this article is available as a PDF (1.3 MB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Francis T., Tillett W. S. CUTANEOUS REACTIONS IN PNEUMONIA. THE DEVELOPMENT OF ANTIBODIES FOLLOWING THE INTRADERMAL INJECTION OF TYPE-SPECIFIC POLYSACCHARIDE. J Exp Med. 1930 Sep 30;52(4):573–585. doi: 10.1084/jem.52.4.573. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goebel W. F., Avery O. T. CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : I. THE SYNTHESIS OFp-AMINOPHENOL beta-GLUCOSIDE, p-AMINOPHENOL beta-GALACTOSIDE, AND THEIR COUPLING WITH SERUM GLOBULIN. J Exp Med. 1929 Sep 30;50(4):521–531. doi: 10.1084/jem.50.4.521. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Heidelberger M., Avery O. T. THE SOLUBLE SPECIFIC SUBSTANCE OF PNEUMOCOCCUS : SECOND PAPER. J Exp Med. 1924 Aug 31;40(3):301–317. doi: 10.1084/jem.40.3.301. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Heidelberger M., Goebel W. F., Avery O. T. THE SOLUBLE SPECIFIC SUBSTANCE OF PNEUMOCOCCUS : THIRD PAPER. J Exp Med. 1925 Oct 31;42(5):727–745. doi: 10.1084/jem.42.5.727. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jones F. S. AGGLUTINATION BY PRECIPITIN : SECOND PAPER. J Exp Med. 1928 Jul 31;48(2):183–192. doi: 10.1084/jem.48.2.183. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jones F. S. AGGLUTINATION BY PRECIPITIN. J Exp Med. 1927 Jul 31;46(2):303–314. doi: 10.1084/jem.46.2.303. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mudd S., Lucké B., McCutcheon M., Strumia M. ON THE MECHANISM OF OPSONIN AND BACTERIOTROPIN ACTION : VI. AGGLUTINATION AND TROPIN ACTION BY PRECIPITIN SERA. CHARACTERIZATION OF THE SENSITIZED SURFACE. J Exp Med. 1930 Aug 31;52(3):313–329. doi: 10.1084/jem.52.3.313. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nishimura S. THE ANTIBODY-FORMATION BY POLYSACCHARIDS. J Exp Med. 1929 Sep 30;50(4):419–430. doi: 10.1084/jem.50.4.419. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rhoads C. P. IMMUNIZATION WITH ALUMINUM HYDROXIDE MIXTURES OF POLIOMYELITIS VIRUS. Science. 1930 Dec 12;72(1876):608–608. doi: 10.1126/science.72.1876.608. [DOI] [PubMed] [Google Scholar]