Abstract
Scrapings of subcutaneous nodules from ten patients with rheumatic fever were examined microscopically after being stained with supravital dyes. From the uniform results obtained, the following conclusions have been drawn. 1. Supravital staining of cells from these lesions gives information unobtainable with ordinary histologic methods. 2. The scrapings show a great predominance of certain cells almost entirely devoid of phagocytic power and not characterized by the reactions with neutral red which distinguish monocytes, epithelioid cells, and clasmatocytes. Hence they differ from the essential cells of the lesions of tuberculosis and experimental syphilis. These differences are probably of a functional and developmental rather than of a genetic nature. 3. The cells probably arise from the undifferentiated mesenchymal elements of loose connective tissue, although it is possible that endothelial cells take part in their formation in some instances. 4. Since there is little doubt that the subcutaneous rheumatic nodules are pathologically identical with rheumatic granulomata else-where in the body, these conclusions are considered applicable also to the Aschoff body cells of the myocardial submiliary nodules.
Full Text
The Full Text of this article is available as a PDF (1,021.6 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Cecil R. L. A STUDY OF EXPERIMENTAL NON-HEMOLYTIC STREPTOCOCCUS LESIONS IN VITALLY STAINED RABBITS. J Exp Med. 1916 Dec 1;24(6):739–758. doi: 10.1084/jem.24.6.739. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Coates V. Tissue Reaction in Disorders of the Rheumatic Group: with particular reference to Subcutaneous Nodules. Proc R Soc Med. 1930 Mar;23(5):587–596. [PMC free article] [PubMed] [Google Scholar]
- Gross L., Loewe L., Eliasoph B. ATTEMPTS TO REPRODUCE RHEUMATIC FEVER IN ANIMALS. J Exp Med. 1929 Jun 30;50(1):41–65. doi: 10.1084/jem.50.1.41. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Miller F. R. THE INDUCED DEVELOPMENT AND HISTOGENESIS OF PLASMA CELLS. J Exp Med. 1931 Jul 31;54(3):333–347. doi: 10.1084/jem.54.3.333. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rinehart J. F. Reticulum. Its Origin. The Occurrence of Reticulum Fibrils in Capillary Endothelium. A New Method Of Demonstration. II. The Finer Capillary Bed. Am J Pathol. 1930 Sep;6(5):525–540.11. [PMC free article] [PubMed] [Google Scholar]
- Sabin F. R., Doan C. A. THE PRESENCE OF DESQUAMATED ENDOTHELIAL CELLS, THE SO CALLED CLASMATOCYTES, IN NORMAL MAMMALIAN BLOOD. J Exp Med. 1926 May 31;43(6):823–837. doi: 10.1084/jem.43.6.823. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sabin F. R., Doan C. A. THE RELATION OF MONOCYTES AND CLASMATOCYTES TO EARLY INFECTION IN RABBITS WITH BOVINE TUBERCLE BACILLI. J Exp Med. 1927 Sep 30;46(4):627–644. doi: 10.1084/jem.46.4.627. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Swift H. F. THE PATHOGENESIS OF RHEUMATIC FEVER. J Exp Med. 1924 Mar 31;39(4):497–508. doi: 10.1084/jem.39.4.497. [DOI] [PMC free article] [PubMed] [Google Scholar]