Abstract
1. Following repeated intracutaneous injections of heat-killed S or R pneumococci, rabbits acquire an increased skin reactivity to the nucleoprotein of both Pneumococcus and indifferent Streptococcus. 2. Rabbits acquire a skin reactivity to the proteins of both the organisms mentioned after receiving intracutaneous injections of heat-killed indifferent streptococci. 3. Injections of pneumococci into the skin are followed in some rabbits by an eye sensitivity to pneumococcus protein but not to streptococcus protein nor to suspensions of either living organism. 4. Injections of indifferent streptococci into the skin are followed, in some rabbits, by an eye sensitivity to suspensions of live indifferent Streptococcus, but not to R Pneumococcus or to the nucleoprotein of either organism. Measured in terms of bacterial specificity therefore, the eye sensitivity possesses a specificity which is not shared by the skin sensitivity. 5. The sera of rabbits injected intracutaneously with pneumococci or indifferent streptococci contain agglutinins for both R Pneurnococcus and indifferent Streptococcus. 6. Only those animals injected with pneumococci acquire resistance to pneumococcal infection.
Full Text
The Full Text of this article is available as a PDF (445.9 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Andrewes C. H., Derick C. L., Swift H. F. THE SKIN RESPONSE OF RABBITS TO NON-HEMOLYTIC STREPTOCOCCI : I. DESCRIPTION OF A SECONDARY REACTION OCCURRING LOCALLY AFTER INTRADERMAL INOCULATION. J Exp Med. 1926 Jun 30;44(1):35–53. doi: 10.1084/jem.44.1.35. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Derick C. L., Swift H. F. REACTIONS OF RABBITS TO NON-HEMOLYTIC STREPTOCOCCI : I. GENERAL TUBERCULIN-LIKE HYPERSENSITIVENESS, ALLERGY, OR HYPERERGY FOLLOWING THE SECONDARY REACTION. J Exp Med. 1929 Mar 31;49(4):615–636. doi: 10.1084/jem.49.4.615. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Heidelberger M., Goebel W. F., Avery O. T. THE SOLUBLE SPECIFIC SUBSTANCE OF A STRAIN OF FRIEDLANDER'S BACILLUS : PAPER I. J Exp Med. 1925 Oct 31;42(5):701–707. doi: 10.1084/jem.42.5.701. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hitchcock C. H. SEROLOGICAL RELATIONSHIPS AMONG AND BETWEEN THE STREPTOCOCCI AND PNEUMOCOCCI. J Exp Med. 1925 Jan 1;41(1):13–23. doi: 10.1084/jem.41.1.13. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hitchcock C. H., Swift H. F. STUDIES ON INDIFFERENT STREPTOCOCCI : III. THE ALLERGIZING CAPACITY OF DIFFERENT STRAINS. J Exp Med. 1929 Mar 31;49(4):637–647. doi: 10.1084/jem.49.4.637. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Julianelle L. A. REACTIONS OF RABBITS TO INTRACUTANEOUS INJECTIONS OF PNEUMOCOCCI AND THEIR PRODUCTS : I. THE ANTIBODY RESPONSE. J Exp Med. 1930 Feb 28;51(3):441–448. doi: 10.1084/jem.51.3.441. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Julianelle L. A. REACTIONS OF RABBITS TO INTRACUTANEOUS INJECTIONS OF PNEUMOCOCCI AND THEIR PRODUCTS : II. RESISTANCE TO INFECTION. J Exp Med. 1930 Feb 28;51(3):449–462. doi: 10.1084/jem.51.3.449. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Julianelle L. A. REACTIONS OF RABBITS TO INTRACUTANEOUS INJECTIONS OF PNEUMOCOCCI AND THEIR PRODUCTS : IV. THE DEVELOPMENT OF SKIN REACTIVITY TO DERIVATIVES OF PNEUMOCOCCUS. J Exp Med. 1930 Mar 31;51(4):625–632. doi: 10.1084/jem.51.4.625. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Julianelle L. A. REACTIONS OF RABBITS TO INTRACUTANEOUS INJECTIONS OF PNEUMOCOCCI AND THEIR PRODUCTS : V. THE DEVELOPMENT OF EYE REACTIVITY TO DERIVATIVES OF PNEUMOCOCCI. J Exp Med. 1930 Mar 31;51(4):633–642. doi: 10.1084/jem.51.4.633. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lancefield R. C. THE IMMUNOLOGICAL RELATIONSHIPS OF STREPTOCOCCUS VIRIDANS AND CERTAIN OF ITS CHEMICAL FRACTIONS : I. SEROLOGICAL REACTIONS OBTAINED WITH ANTIBACTERIAL SERA. J Exp Med. 1925 Aug 31;42(3):377–395. doi: 10.1084/jem.42.3.377. [DOI] [PMC free article] [PubMed] [Google Scholar]