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The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1933 Jan 31;57(2):305–333. doi: 10.1084/jem.57.2.305

STUDIES ON THE SUPRARENAL CORTEX

I. CORTICAL SUPRARENAL INSUFFICIENCY AND THE ACTION OF THE CORTICAL HORMONE UPON THE NORMAL AND SUPRARENALECTOMIZED DOG

George A Harrop Jr 1, Albert Weinstein 1
PMCID: PMC2132226  PMID: 19870132

Abstract

1. The methods used in the operation and care of suprarenalectomized dogs are given. 2. The effect of injections of the cortical hormone upon normal and suprarenalectomized dogs is described. 3. Symptoms and chemical studies of suprarenal insufficiency in the dog, following extract withdrawal are described, together with the effects produced by its readministration. 4. The phenomena associated with experimental suprarenal insufficiency are contrasted with those seen in patients with Addison's disease. The identity of the acute symptoms with those of "shock" is pointed out.

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Selected References

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  1. Annau E., Huszák S., Svirbely J. L., Szent-Györgyi A. The function of the adrenal medulla. J Physiol. 1932 Oct 4;76(2):181–186. doi: 10.1113/jphysiol.1932.sp002919. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Harrop G. A., Pfiffner J. J., Weinstein A., Swingle W. W. FURTHER STUDIES ON THE ADRENAL CORTICAL HORMONE. Science. 1931 Jun 19;73(1903):683–684. doi: 10.1126/science.73.1903.683. [DOI] [PubMed] [Google Scholar]

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