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The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1933 Feb 28;57(3):373–379. doi: 10.1084/jem.57.3.373

STUDIES ON THE PRECIPITIN REACTION

PRECIPITATING HAPTENS; SPECIES DIFFERENCES IN ANTIBODIES

Michael Heidelberger 1, Forrest E Kendall 1
PMCID: PMC2132235  PMID: 19870136

Abstract

1. Partial hydrolysis products of the specific polysaccharide of Type III pneumococcus ranging from 550 to 1,800 in formula weight can be quantitatively freed from unhydrolyzed polysaccharide. 2. The fractions yield specific precipitates with Type III antipneumococcus horse serum but fail to precipitate homologous rabbit antisera, giving rise only to specific inhibition. The aldobionic acid, the structural unit of S III, does not precipitate antisera. 3. A possible explanation and a possible application of the findings are pointed out.

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Selected References

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  1. Heidelberger M., Kendall F. E. A QUANTITATIVE STUDY OF THE PRECIPITIN REACTION BETWEEN TYPE III PNEUMOCOCCUS POLYSACCHARIDE AND PURIFIED HOMOLOGOUS ANTIBODY. J Exp Med. 1929 Nov 30;50(6):809–823. doi: 10.1084/jem.50.6.809. [DOI] [PMC free article] [PubMed] [Google Scholar]
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