Abstract
Pseudorabies virus, Iowa strain ("mad itch"), after passage through guinea pig brain, fails to produce infection in guinea pigs when injected subcutaneously unless enormous doses are employed. Such virus is still pathogenic for rabbits when given subcutaneously and for rabbits and guinea pigs intracerebrally. Comparison of the amounts of virus present in the brains of rabbits and guinea pigs following fatal cerebral infection shows that the latter contain, per gram, only approximately one-tenth the amount of virus in the former. Comparing the resistance of the two species to subcutaneously administered pseudorabies virus it has been found that rabbits are approximately 100 times more susceptible than guinea pigs. Over and above the working of these two factors, guinea pig passage appears to achieve some actual attenuation of virus when tested by subcutaneous inoculation into guinea pigs.
Full Text
The Full Text of this article is available as a PDF (309.1 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Shope R. E. AN EXPERIMENTAL STUDY OF "MAD ITCH" WITH ESPECIAL REFERENCE TO ITS RELATIONSHIP TO PSEUDORABIES. J Exp Med. 1931 Jul 31;54(2):233–248. doi: 10.1084/jem.54.2.233. [DOI] [PMC free article] [PubMed] [Google Scholar]