Abstract
Invasive strains of staphylococcus and streptococcus contain a soluble factor which markedly increases tissue permeability and enhances the infections produced by these organisms, by other bacteria, and by vaccine virus as well. The non-invasive strains of the same species of staphylococci and streptococci do not contain this factor. The enhancing substance elaborated locally by organisms passes into the circulating blood and bringing about a general increase of tissue permeability may act to enhance local infections elsewhere. The factor is similar in the phenomena it elicits to the spreading factor extracted from many animal tissues, especially from testicle.
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Selected References
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- Duran-Reynals F. THE EFFECT OF ANTITESTICULAR SERUM ON THE ENHANCEMENT VALUE OF TESTICLE EXTRACT. J Exp Med. 1932 Apr 30;55(5):703–712. doi: 10.1084/jem.55.5.703. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Duran-Reynals F. THE EFFECT OF EXTRACTS OF CERTAIN ORGANS FROM NORMAL AND IMMUNIZED ANIMALS ON THE INFECTING POWER OF VACCINE VIRUS. J Exp Med. 1929 Aug 31;50(3):327–340. doi: 10.1084/jem.50.3.327. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Favilli G. THE EFFECT OF TESTICLE EXTRACT ON RED BLOOD CELLS IN VITRO. J Exp Med. 1931 Jul 31;54(2):197–206. doi: 10.1084/jem.54.2.197. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goodner K. THE DEVELOPMENT AND LOCALIZATION OF THE DERMAL PNEUMOCOCCIC LESION IN THE RABBIT. J Exp Med. 1931 Nov 30;54(6):847–858. doi: 10.1084/jem.54.6.847. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goodner K. THE EFFECT OF PNEUMOCOCCUS AUTOLYSATES UPON PNEUMOCOCCUS DERMAL INFECTION IN THE RABBIT. J Exp Med. 1933 Jul 31;58(2):153–160. doi: 10.1084/jem.58.2.153. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Heidelberger M., Avery O. T. THE SOLUBLE SPECIFIC SUBSTANCE OF PNEUMOCOCCUS. J Exp Med. 1923 Jun 30;38(1):73–79. doi: 10.1084/jem.38.1.73. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hoffman D. C., Duran-Reynals F. THE INFLUENCE OF TESTICLE EXTRACT ON THE INTRADERMAL SPREAD OF INJECTED FLUIDS AND PARTICLES. J Exp Med. 1931 Feb 28;53(3):387–398. doi: 10.1084/jem.53.3.387. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nigg C., Landsteiner K. STUDIES ON THE CULTIVATION OF THE TYPHUS FEVER RICKETTSIA IN THE PRESENCE OF LIVE TISSUE. J Exp Med. 1932 Mar 31;55(4):563–576. doi: 10.1084/jem.55.4.563. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rivers T. M. SKIN INFECTION OF RABBITS WITH HEMOLYTIC STREPTOCOCCI ISOLATED FROM A PATIENT WITH ERYSIPELAS : I. METHOD OF DEMONSTRATING PROTECTIVE ACTION OF IMMUNE SERA. J Exp Med. 1925 Jan 31;41(2):179–184. doi: 10.1084/jem.41.2.179. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shope R. E. SWINE INFLUENZA : III. FILTRATION EXPERIMENTS AND ETIOLOGY. J Exp Med. 1931 Jul 31;54(3):373–385. doi: 10.1084/jem.54.3.373. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shwartzman G. THE EFFECT OF BACTERIAL VARIATION UPON THE FACTORS NECESSARY FOR THE PHENOMENON OF LOCAL SKIN REACTIVITY TO BACTERIAL FILTRATES. J Exp Med. 1930 Oct 31;52(5):781–803. doi: 10.1084/jem.52.5.781. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stewart F. W., Duran-Reynals F. A STUDY OF THE GENERALIZATION OF VACCINE VIRUS FROM ENHANCED SKIN LESIONS. J Exp Med. 1929 Aug 31;50(3):341–353. doi: 10.1084/jem.50.3.341. [DOI] [PMC free article] [PubMed] [Google Scholar]