Abstract
By means of the reaction to intracutaneous inoculation with bacterial suspensions in amounts of 0.2 cc., bacterial allergy was demonstrated in rabbits into which had been implanted agar foci containing either gonococci, meningococci, M. catarrhalis, or Bact. lepisepticum. The criterion of hypersensitiveness was the relative size and intensity of reaction evoked by an identical dose in "agar focus" and control rabbits. Rabbits sensitized to gonococci or meningococci usually reacted indistinguishably to either of these organisms, but were less allergic to M. catarrhalis. Similarly, animals sensitized to M. catarrhalis gave moderate but not maximal responses to the two former organisms. Cross-reactions did not occur between Bact. lepisepticum and any of the three Neisseriae. Animals sensitized to the four organisms mentioned reacted no more intensely than did controls to hemolytic streptococci, staphylococci, and rough pneumococci. The hypersensitive state was found to begin early in the 2nd week and to end usually by the 4th week, being at its height in most instances on the 10th to 12th days. The number of organisms contained in the agar focus determined the success of the sensitization only to this extent, that very small and very large inocula failed to evoke the allergic state. Rabbits immunized by intravenous injection of live organisms developed cutaneous reactions indistinguishable from those in controls. The "secondary rise" of Andrewes, Derick, and Swift was rarely observed.
Full Text
The Full Text of this article is available as a PDF (786.8 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Andrewes C. H., Derick C. L., Swift H. F. THE SKIN RESPONSE OF RABBITS TO NON-HEMOLYTIC STREPTOCOCCI : I. DESCRIPTION OF A SECONDARY REACTION OCCURRING LOCALLY AFTER INTRADERMAL INOCULATION. J Exp Med. 1926 Jun 30;44(1):35–53. doi: 10.1084/jem.44.1.35. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Derick C. L., Andrewes C. H. THE SKIN RESPONSE OF RABBITS TO NON-HEMOLYTIC STREPTOCOCCI : II. ATTEMPTS TO DETERMINE WHETHER THE SECONDARY REACTION IS OF THE NATURE OF AN ARTHUS PHENOMENON. J Exp Med. 1926 Jun 30;44(1):55–64. doi: 10.1084/jem.44.1.55. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Derick C. L., Hitchcock C. H., Swift H. F. REACTIONS OF RABBITS TO NON-HEMOLYTIC STREPTOCOCCI : III. A STUDY OF MODES OF SENSITIZATION. J Exp Med. 1930 Jun 30;52(1):1–22. doi: 10.1084/jem.52.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Derick C. L., Swift H. F. REACTIONS OF RABBITS TO NON-HEMOLYTIC STREPTOCOCCI : I. GENERAL TUBERCULIN-LIKE HYPERSENSITIVENESS, ALLERGY, OR HYPERERGY FOLLOWING THE SECONDARY REACTION. J Exp Med. 1929 Mar 31;49(4):615–636. doi: 10.1084/jem.49.4.615. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gates F. L. A METHOD OF STANDARDIZING BACTERIAL SUSPENSIONS. J Exp Med. 1920 Jan 1;31(1):105–114. doi: 10.1084/jem.31.1.105. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mackenzie G. M., Woo S. T. THE PRODUCTION AND SIGNIFICANCE OF CUTANEOUS ALLERGY TO PNEUMOCOCCUS PROTEIN. J Exp Med. 1925 Jan 1;41(1):65–71. doi: 10.1084/jem.41.1.65. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Miller A. P., Cook R. E. PUBLIC HEALTH ENGINEERING: SANITARY ENGINEERING IN A COUNTY HEALTH DEPARTMENT. Am J Public Health Nations Health. 1931 Sep;21(9):1044–1050. doi: 10.2105/ajph.21.9.1044. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Miller C. P., Hastings A. B., Castles R. The Influence of Inorganic Salts on the Multiplication of Gonococcus. J Bacteriol. 1932 Dec;24(6):439–455. doi: 10.1128/jb.24.6.439-455.1932. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Swift H. F., Derick C. L. REACTIONS OF RABBITS TO NON-HEMOLYTIC STREPTOCOCCI : II. SKIN REACTIONS IN INTRAVENOUSLY IMMUNIZED ANIMALS. J Exp Med. 1929 Apr 30;49(5):883–897. doi: 10.1084/jem.49.5.883. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zinsser H., Parker J. T. FURTHER STUDIES ON BACTERIAL HYPERSUSCEPTIBILITY. II. J Exp Med. 1923 Jan 31;37(2):275–302. doi: 10.1084/jem.37.2.275. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zinsser H., Tamiya T. AN EXPERIMENTAL ANALYSIS OF BACTERIAL ALLERGY. J Exp Med. 1926 Nov 30;44(6):753–776. doi: 10.1084/jem.44.6.753. [DOI] [PMC free article] [PubMed] [Google Scholar]