Abstract
Evidence is presented that the proliferating gall bladder epithelium in the dog and guinea pig is capable of stimulating bone formation in certain connective tissues such as the abdominal wall. Other connective tissue areas such as the subepithelial connective tissue of the gall bladder and urinary bladder do not share in this tissue reaction and resist the bone stimulus of the epithelium. The formation of bone in these circumstances is thus biphasic. A difference between connective tissues morphologically identical can be proven physiologically, by their response to the osteogenic stimulus of appropriate epithelia. Calcium carbonate microliths occurred in the mucus of the occluded gall bladder in which there was transplanted connective tissue forming part of the wall.
Full Text
The Full Text of this article is available as a PDF (733.0 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Huggins C. B. The phosphatase activity of transplants of the epithelium of the urinary bladder to the abdominal wall producing heterotopic ossification. Biochem J. 1931;25(3):728–732. doi: 10.1042/bj0250728. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Parker R. C. THE FUNCTIONAL CHARACTERISTICS OF NINE RACES OF FIBROBLASTS. Science. 1932 Sep 2;76(1966):219–220. doi: 10.1126/science.76.1966.219-a. [DOI] [PubMed] [Google Scholar]
- Parker R. C. THE STABILITY OF FUNCTIONALLY DISTINCT RACES OF FIBROBLASTS. Science. 1932 Nov 11;76(1976):446–447. doi: 10.1126/science.76.1976.446. [DOI] [PubMed] [Google Scholar]
- Phemister D. B., Day L., Hastings A. B. CALCIUM CARBONATE GALL-STONES AND THEIR EXPERIMENTAL PRODUCTION. Ann Surg. 1932 Oct;96(4):595–614. doi: 10.1097/00000658-193210000-00011. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Phemister D. B., Rewbridge A. G., Rudisill H. CALCIUM CARBONATE GALL-STONES AND CALCIFICATION OF THE GALL-BLADDER FOLLOWING CYSTIC-DUCT OBSTRUCTION. Ann Surg. 1931 Oct;94(4):493–516. doi: 10.1097/00000658-193110000-00003. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rous P., McMaster P. D., Drury D. R. OBSERVATIONS ON SOME CAUSES OF GALL STONE FORMATION : I. EXPERIMENTAL CHOLELITHIASIS IN THE ABSENCE OF STASIS, INFECTION, AND GALL BLADDER INFLUENCES. J Exp Med. 1924 Jan 1;39(1):77–96. doi: 10.1084/jem.39.1.77. [DOI] [PMC free article] [PubMed] [Google Scholar]