Abstract
The experiments described confirm the earlier observation of Smith, Andrewes, and Laidlaw that the swine influenza virus is pathogenic for ferrets when administered intranasally. A disease that is clinically more severe and pathologically more extensive than that described by the above workers is obtained if inoculation with the virus is performed under ether anesthesia. Animals infected in this way show at autopsy an edematous type of pneumonia of lobar distribution which may terminate fatally. The virus maintains its pathogenicity for ferrets when stored in 50 per cent glycerol at refrigerator temperature for as long as 75 days. After serial passage through 16 ferrets the virus is still capable of inducing swine influenza when mixed with H. influenzae suis and administered intranasally to swine. Ferret passage causes no apparent attenuation of the virus for swine. Serum from pigs recovered from swine influenza is capable of neutralizing the ferret-passaged virus for either swine or ferrets. Likewise serum from recovered ferrets neutralizes the swine influenza virus for either ferrets or swine.
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Selected References
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- Lewis P. A., Shope R. E. SWINE INFLUENZA : II. A HEMOPHILIC BACILLUS FROM THE RESPIRATORY TRACT OF INFECTED SWINE. J Exp Med. 1931 Jul 31;54(3):361–371. doi: 10.1084/jem.54.3.361. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shope R. E. STUDIES ON IMMUNITY TO SWINE INFLUENZA. J Exp Med. 1932 Sep 30;56(4):575–585. doi: 10.1084/jem.56.4.575. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shope R. E. SWINE INFLUENZA : I. EXPERIMENTAL TRANSMISSION AND PATHOLOGY. J Exp Med. 1931 Jul 31;54(3):349–359. doi: 10.1084/jem.54.3.349. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shope R. E. SWINE INFLUENZA : III. FILTRATION EXPERIMENTS AND ETIOLOGY. J Exp Med. 1931 Jul 31;54(3):373–385. doi: 10.1084/jem.54.3.373. [DOI] [PMC free article] [PubMed] [Google Scholar]