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The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1934 Jun 30;60(1):1–7. doi: 10.1084/jem.60.1.1

THE PRODUCTION OF STREPTOCOCCUS HEMOLYTICUS BACTEREMIA IN NON-SPECIFICALLY SENSITIZED ANIMALS

Caspar G Burn 1, Caroline A Chandler 1, Mildred Hartshorn 1
PMCID: PMC2132387  PMID: 19870280

Abstract

Rabbits sensitized to horse serum developed a bacteremia of 9 to 12 hours' duration when they were inoculated simultaneously with normal horse serum and a strain of Streptococcus hemolyticus, while the bacteria could only be isolated from the blood stream of non-sensitized animals within the first 3 hours after inoculation. On the other hand, when antisera are employed as the antigen for shocking the sensitized rabbits, there is a significant increase in the number of bacteria in the blood stream in contrast to the control animals, but there is no evidence of a prolongation of the bacteremia.

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