Abstract
The fibrinolysin of hemolytic streptococci exerts no hydrolytic action upon casein, gelatin, or peptone. The action on solid human fibrin is characterized by a small and gradual increase in the amino nitrogen content of the solution. The specific and special enzymatic action of fibrinolysin is contrasted with trypsin and with streptococcal peptase (4). Solutions of human fibrinogen, after brief incubation with fibrinolysin, lose the capacity to form fibrin. Solutions of rabbit fibrinogen, on the other hand, retain the property of transformation into fibrin, even after prolonged exposure to fibrinolysin. Qualitative tests, with solutions resulting from the action of streptococcal fibrinolysin on human fibrin, indicate that the end-product may be protein and that the degradation of the molecule is not great.
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Selected References
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- Garner R. L., Tillett W. S. BIOCHEMICAL STUDIES ON THE FIBRINOLYTIC ACTIVITY OF HEMOLYTIC STREPTOCOCCI : I. ISOLATION AND CHARACTERIZATION OF FIBRINOLYSIN. J Exp Med. 1934 Jul 31;60(2):239–254. doi: 10.1084/jem.60.2.239. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Johlin J. M., Avery R. C. THE EXTRACTION OF THE CELL CONTENT OF MICRO-ORGANISMS BY PERCUSSION OF THE FROZEN CELLS. J Exp Med. 1930 Aug 31;52(3):417–420. doi: 10.1084/jem.52.3.417. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stevens F. A., West R. THE PEPTASE, LIPASE, AND INVERTASE OF HEMOLYTIC STREPTOCOCCUS. J Exp Med. 1922 May 31;35(6):823–846. doi: 10.1084/jem.35.6.823. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tillett W. S., Garner R. L. THE FIBRINOLYTIC ACTIVITY OF HEMOLYTIC STREPTOCOCCI. J Exp Med. 1933 Sep 30;58(4):485–502. doi: 10.1084/jem.58.4.485. [DOI] [PMC free article] [PubMed] [Google Scholar]