Abstract
Extracts of desiccated homologous embryo skin and placenta decrease markedly the rate of postoperative local recurrence after the surgical removal of spontaneous cancer of mice. Autografts after a short period of contact with these extracts either failed to grow, or, in the majority of instances, their subsequent growth was definitely retarded. Intraperitoneal injection of the extracts was followed by cessation of growth of established tumors in more than two-thirds of the animals treated, and among these many of the tumors regressed and over 20 per cent were completely absorbed. Tumor mice treated with either extract rarely developed new malignant foci, though this happened frequently in untreated mice.
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Selected References
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- Murphy J. B., Morton J. J. THE EFFECT OF ROENTGEN RAYS ON THE RATE OF GROWTH OF SPONTANEOUS TUMORS IN MICE. J Exp Med. 1915 Dec 1;22(6):800–803. doi: 10.1084/jem.22.6.800. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Murphy J. B., Sturm E. EFFECT OF INHIBITING FACTOR FROM NORMAL TISSUES ON SPONTANEOUS TUMORS OF MICE. Science. 1933 Jun 30;77(2009):631–633. doi: 10.1126/science.77.2009.631. [DOI] [PubMed] [Google Scholar]
- Murphy J. B., Sturm E. NORMAL TISSUES AS A POSSIBLE SOURCE OF INHIBITOR FOR TUMORS. Science. 1932 May 20;75(1951):540–541. doi: 10.1126/science.75.1951.540. [DOI] [PubMed] [Google Scholar]
- Nakahara W. RESISTANCE TO SPONTANEOUS MOUSE CANCER INDUCED BY INJECTIONS OF OLEIC ACID. J Exp Med. 1925 Feb 28;41(3):347–356. doi: 10.1084/jem.41.3.347. [DOI] [PMC free article] [PubMed] [Google Scholar]