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. 1990 Aug;172(8):4710–4714. doi: 10.1128/jb.172.8.4710-4714.1990

Cloning of a lincosamide resistance determinant from Streptomyces caelestis, the producer of celesticetin, and characterization of the resistance mechanism.

M J Calcutt 1, E Cundliffe 1
PMCID: PMC213311  PMID: 2376570

Abstract

Self-resistance has been investigated in Streptomyces caelestis (producer of the lincosamide antibiotic celesticetin), from which a lincosamide resistance determinant (clr) has been isolated on a 1-kilobase DNA fragment and cloned in Streptomyces lividans. The clr product is a specific methylase which produces a single residue of N6-monomethyladenine in 23S rRNA at position 2058, thereby rendering the 50S ribosmal subunit resistant to the action of lincosamides.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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