Abstract
Growth in the presence of glucose, even under highly aerobic conditions, significantly reduced the activities of three tricarboxylic acid cycle enzymes, citrate synthetase, alpha-ketoglutarate dehydrogenase, and malate dehydrogenase, in suicidal but not nonsuicidal Aeromonas strains. Pyruvate dehydrogenase activity, however, was significantly increased. The activities of all of the enzymes, as well as the glucose-mediated increase in acetic acid production, were shown to be regulated by catabolite repression. The regulator protein is the same one which regulates the utilization of several sugars.
Full text
PDF



Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Amarasingham C. R., Davis B. D. Regulation of alpha-ketoglutarate dehydrogenase formation in Escherichia coli. J Biol Chem. 1965 Sep;240(9):3664–3668. [PubMed] [Google Scholar]
- Broman R. L., Dobrogosz W. J. Stimulation of cytochrome synthesis in Escherichia coli by cyclic AMP. Arch Biochem Biophys. 1974 Jun;162(2):595–601. doi: 10.1016/0003-9861(74)90220-3. [DOI] [PubMed] [Google Scholar]
- Dietrich J., Henning U. Regulation of pyruvate dehydrogenase complex synthesis in Escherichia coli K 12. Identification of the inducing metabolite. Eur J Biochem. 1970 Jun;14(2):258–269. doi: 10.1111/j.1432-1033.1970.tb00285.x. [DOI] [PubMed] [Google Scholar]
- Dills S. E., Dobrogosz W. J. Cyclic adenosine 3',5'-monophosphate regulation of membrane energetics in Escherichia coli. J Bacteriol. 1977 Sep;131(3):854–865. doi: 10.1128/jb.131.3.854-865.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Emmer M., deCrombrugghe B., Pastan I., Perlman R. Cyclic AMP receptor protein of E. coli: its role in the synthesis of inducible enzymes. Proc Natl Acad Sci U S A. 1970 Jun;66(2):480–487. doi: 10.1073/pnas.66.2.480. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Flechtner V. R., Hanson R. S. Regulation of the tricarboxylic acid cycle in bacteria. A comparison of citrate synthases from different bacteria. Biochim Biophys Acta. 1970 Nov 24;222(2):253–264. doi: 10.1016/0304-4165(70)90114-5. [DOI] [PubMed] [Google Scholar]
- Fortnagel P., Freese E. Analysis of sporulation mutants. II. Mutants blocked in the citric acid cycle. J Bacteriol. 1968 Apr;95(4):1431–1438. doi: 10.1128/jb.95.4.1431-1438.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gray C. T., Wimpenny J. W., Mossman M. R. Regulation of metabolism in facultative bacteria. II. Effects of aerobiosis, anaerobiosis and nutrition on the formation of Krebs cycle enzymes in Escherichia coli. Biochim Biophys Acta. 1966 Mar 28;117(1):33–41. doi: 10.1016/0304-4165(66)90149-8. [DOI] [PubMed] [Google Scholar]
- HALPERN Y. S., EVEN-SHOSHAN A., ARTMAN M. EFFECT OF GLUCOSE ON THE UTILIZATION OF SUCCINATE AND THE ACTIVITY OF TRICARBOXYLIC ACID-CYCLE ENZYMES IN ESCHERICHIA COLI. Biochim Biophys Acta. 1964 Nov 8;93:228–236. doi: 10.1016/0304-4165(64)90370-8. [DOI] [PubMed] [Google Scholar]
- Martin-Requero A., Corkey B. E., Cerdan S., Walajtys-Rode E., Parrilla R. L., Williamson J. R. Interactions between alpha-ketoisovalerate metabolism and the pathways of gluconeogenesis and urea synthesis in isolated hepatocytes. J Biol Chem. 1983 Mar 25;258(6):3673–3681. [PubMed] [Google Scholar]
- Namdari H., Cabelli V. J. The suicide phenomenon in motile aeromonads. Appl Environ Microbiol. 1989 Mar;55(3):543–547. doi: 10.1093/benz/9780199773787.article.b00013623. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ohné M. Regulation of the dicarboxylic acid part of the citric acid cycle in Bacillus subtilis. J Bacteriol. 1975 Apr;122(1):224–234. doi: 10.1128/jb.122.1.224-234.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Perlman R. L., Pastan I. Pleiotropic deficiency of carbohydrate utilization in an adenyl cyclase deficient mutant of Escherichia coli. Biochem Biophys Res Commun. 1969 Sep 24;37(1):151–157. doi: 10.1016/0006-291x(69)90893-6. [DOI] [PubMed] [Google Scholar]
- Takahashi Y. Effect of glucose and cyclic adenosine 3',5'-monophosphate on the synthesis of succinate dehydrogenase and isocitrate lyase in Escherichia coli. J Biochem. 1975 Nov;78(5):1097–1100. doi: 10.1093/oxfordjournals.jbchem.a130987. [DOI] [PubMed] [Google Scholar]