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The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1935 Jun 30;62(1):23–30. doi: 10.1084/jem.62.1.23

THE IMMUNOLOGICAL SPECIFICITY OF STAPHYLOCOCCI

II. THE CHEMICAL NATURE OF THE SOLUBLE SPECIFIC SUBSTANCES

C W Wieghard 1, L A Julianelle 1
PMCID: PMC2133257  PMID: 19870399

Abstract

1. Two carbohydrates have been extracted from different strains of Staphylococcus which are immunologically and chemically distinct. 2. The chemical differences between the two types are manifested principally in optical rotation, and in the simple sugars resulting from hydrolytic cleavage of the specific carbohydrates. 3. The immunological specificity of both polysaccharides is dissipated as hydrolysis proceeds. 4. The results of the chemical reactions reported are discussed.

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Selected References

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  1. Heidelberger M., Goebel W. F., Avery O. T. THE SOLUBLE SPECIFIC SUBSTANCE OF PNEUMOCOCCUS : THIRD PAPER. J Exp Med. 1925 Oct 31;42(5):727–745. doi: 10.1084/jem.42.5.727. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Julianelle L. A., Wieghard C. W. THE IMMUNOLOGICAL SPECIFICITY OF STAPHYLOCOCCI : I. THE OCCURRENCE OF SEROLOGICAL TYPES. J Exp Med. 1935 Jun 30;62(1):11–21. doi: 10.1084/jem.62.1.11. [DOI] [PMC free article] [PubMed] [Google Scholar]

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