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The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1935 Jun 30;62(1):101–117. doi: 10.1084/jem.62.1.101

EXPERIMENTS ON THE EPIDEMIOLOGY OF PSEUDORABIES

II. PREVALENCE OF THE DISEASE AMONG MIDDLE WESTERN SWINE AND THE POSSIBLE RÔLE OF RATS IN HERD-TO-HERD INFECTIONS

Richard E Shope 1
PMCID: PMC2133259  PMID: 19870396

Abstract

Study of the pseudorabies virus-neutralizing antibody content of pooled and individual samples of swine serum have led to the conclusion that pseudorabies is a highly prevalent, unrecognized, disease in middle western hogs. It has been shown that wild brown rats develop a fatal infection following ingestion of pseudorabies virus and that their carcasses, in turn, give rise to the disease in swine to which they are fed. It is believed that rats play a rôle in the epidemiology of porcine pseudorabies, serving as the initial source of infection for a swine herd and also as one means by which virus can be spread from farm to farm in swine herds. The experiments presented furnish further evidence that swine may serve as the source of infection for cattle.

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Selected References

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  1. Shope R. E. AN EXPERIMENTAL STUDY OF "MAD ITCH" WITH ESPECIAL REFERENCE TO ITS RELATIONSHIP TO PSEUDORABIES. J Exp Med. 1931 Jul 31;54(2):233–248. doi: 10.1084/jem.54.2.233. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Shope R. E. EXPERIMENTS ON THE EPIDEMIOLOGY OF PSEUDORABIES : I. MODE OF TRANSMISSION OF THE DISEASE IN SWINE AND THEIR POSSIBLE ROLE IN ITS SPREAD TO CATTLE. J Exp Med. 1935 Jun 30;62(1):85–99. doi: 10.1084/jem.62.1.85. [DOI] [PMC free article] [PubMed] [Google Scholar]

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