Abstract
Three cases of Rift Valley fever in human individuals are reported. The virus was recovered from the respiratory tract of the patients and was transmitted to ferrets by the intranasal route. The experimental disease so produced in ferrets is characterized by fever, marked pulmonary lesions, and hemorrhagic phenomena. The results indicate that the virus of Rift Valley fever belongs to the group of filterable viruses which may gain entrance to the human body through the respiratory tract. The differential diagnosis of Rift Valley fever and influenza is discussed. While, clinically, this is a difficult problem, the diagnosis may be readily established through animal experimentation. Certain observations concerning the influence of the route of administration on the protective action of immune serum in serum-virus mixtures are presented.
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Selected References
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- Francis T., Jr TRANSMISSION OF INFLUENZA BY A FILTERABLE VIRUS. Science. 1934 Nov 16;80(2081):457–459. doi: 10.1126/science.80.2081.457-a. [DOI] [PubMed] [Google Scholar]
- Rivers T. M., Berry G. P. PSITTACOSIS : IV. EXPERIMENTALLY INDUCED INFECTIONS IN MONKEYS. J Exp Med. 1931 Jun 30;54(1):129–144. doi: 10.1084/jem.54.1.129. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schwentker F. F., Rivers T. M. RIFT VALLEY FEVER IN MAN : REPORT OF A FATAL LABORATORY INFECTION COMPLICATED BY THROMBOPHLEBITIS. J Exp Med. 1934 Feb 28;59(3):305–313. doi: 10.1084/jem.59.3.305. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shope R. E. THE INFECTION OF FERRETS WITH SWINE INFLUENZA VIRUS. J Exp Med. 1934 Jun 30;60(1):49–61. doi: 10.1084/jem.60.1.49. [DOI] [PMC free article] [PubMed] [Google Scholar]