Abstract
The power of specific antipneumococcus serum to protect mice against infection with Type I Pneumococcus has been studied with reference to the capacity of the animal to utilize the specific antibodies. With a single strain of mice it was found that smaller animals and those with large numbers of white cells in the peritoneal cavity are much better able to utilize the passively conferred immune principles. These two intrinsic factors were resolved into a single element; namely, the number of monocytes in the peritoneal cavity at the time of injection of culture and serum. The interrelation of the extrinsic and intrinsic factors participating in the process of protection have been discussed.
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Selected References
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- Goodner K., Horsfall F. L. THE PROTECTIVE ACTION OF TYPE I ANTIPNEUMOCOCCUS SERUM IN MICE : I. THE QUANTITATIVE ASPECTS OF THE MOUSE PROTECTION TEST. J Exp Med. 1935 Aug 31;62(3):359–374. doi: 10.1084/jem.62.3.359. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goodner K., Miller D. K. THE PROTECTIVE ACTION OF TYPE I ANTIPNEUMOCOCCUS SERUM IN MICE : II. THE COURSE OF THE INFECTIOUS PROCESS. J Exp Med. 1935 Aug 31;62(3):375–391. doi: 10.1084/jem.62.3.375. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goodner K. STUDIES ON HOST FACTORS IN PNEUMOCOCCUS INFECTIONS : II. THE PROTECTIVE ACTION OF TYPE I ANTIPNEUMOCOCCUS SERUM IN RABBITS. J Exp Med. 1934 Jun 30;60(1):19–35. doi: 10.1084/jem.60.1.19. [DOI] [PMC free article] [PubMed] [Google Scholar]