Abstract
Following infection with the virus of influenza, both ferrets and mice develop a state of active immunity to reinfection. The serum of these animals contains neutralizing antibodies, as evidenced by the capacity of the serum to confer passive protection to mice against infection with the P.R.8 and Phila. strains of the virus of human influenza. Rabbits which are apparently insusceptible to infection with the virus of influenza produce specific antibodies in response to repeated injection of virus-containing material. The serum of immunized rabbits affords passive protection to mice against mouse-virulent virus. Although the subcutaneous or intraperitoneal injection of the living virus does not produce infection in mice, animals so treated acquire active immunity against subsequent infection by the intranasal route. Neutralization tests with the serum of patients before and after recovery from influenza, pneumonia and the common cold indicate that neutralizing antibodies arise as a specific response to infection with the virus of influenza. The immunological identity of strains of influenza virus recovered from human sources has been established, and the possible existence of strains of related, but not identical, antigenic structure is discussed.
Full Text
The Full Text of this article is available as a PDF (602.3 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Francis T., Jr TRANSMISSION OF INFLUENZA BY A FILTERABLE VIRUS. Science. 1934 Nov 16;80(2081):457–459. doi: 10.1126/science.80.2081.457-a. [DOI] [PubMed] [Google Scholar]
- Francis T., Magill T. P. RIFT VALLEY FEVER : A REPORT OF THREE CASES OF LABORATORY INFECTION AND THE EXPERIMENTAL TRANSMISSION OF THE DISEASE TO FERRETS. J Exp Med. 1935 Aug 31;62(3):433–448. doi: 10.1084/jem.62.3.433. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shope R. E. SWINE INFLUENZA : III. FILTRATION EXPERIMENTS AND ETIOLOGY. J Exp Med. 1931 Jul 31;54(3):373–385. doi: 10.1084/jem.54.3.373. [DOI] [PMC free article] [PubMed] [Google Scholar]