Skip to main content
The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1936 Jan 1;63(1):17–31. doi: 10.1084/jem.63.1.17

PATHOLOGY OF PNEUMOCOCCUS INFECTION IN MICE FOLLOWING INTRANASAL INSTILLATION

Geoffrey Rake 1
PMCID: PMC2133315  PMID: 19870457

Abstract

Pneumonia can be produced in mice, which have not been previously prepared, by intranasal inoculation of broth cultures of certain strains of pneumococci. Lesions which are quantitatively different can be produced in different breeds of mice by inoculation of the same type of pneumococcus. Similar inoculation of different types of pneumococci into one breed of mice results in lesions which are qualitatively different. In general, these lesions are as follows: a diffuse pneumonia and an acute glomerular nephritis in unselected mice receiving Type I strains; a confluent pneumonia and a tubular nephritis in the case of Type II strains; and as result of Type III strains, an interstitial pneumonia with extensive gelatinous pleurisy, together with necrosis and abscess formation in the spleen and cervical lymph nodes. Resistant strains of mice with Type III pneumococci show slight changes in the lungs, but marked lesions in the spleen and cervical nodes, while susceptible mice with the same type of pneumococcus show marked changes in the lung and moderate lesions in the spleen and cervical nodes. The method of development of Type III pneumonia, studied by means of serial sections of nasally infected mice, appears to proceed in the stages of vascular engorgement, interalveolar interstitial exudate, albuminous fluid exudate into the alveoli and the perivascular lymphatics draining the affected site, and finally, a frank pneumonia with a cellular exudate in the alveoli but without much fibrin.

Full Text

The Full Text of this article is available as a PDF (1.5 MB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blake F. G., Cecil R. L. STUDIES ON EXPERIMENTAL PNEUMONIA : II. PATHOLOGY AND PATHOGENESIS OF PNEUMOCOCCUS LOBAR PNEUMONIA IN MONKEYS. J Exp Med. 1920 Mar 31;31(4):445–474. doi: 10.1084/jem.31.4.445. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Branch A., Stillman E. G. PATHOLOGY OF EXPERIMENTAL PNEUMOCOCCUS PNEUMONIA IN MICE. J Exp Med. 1924 Nov 30;40(6):743–752. doi: 10.1084/jem.40.6.743. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Stillman E. G., Branch A. EXPERIMENTAL PRODUCTION OF PNEUMOCOCCUS PNEUMONIA IN MICE BY THE INHALATION METHOD. J Exp Med. 1924 Nov 30;40(6):733–742. doi: 10.1084/jem.40.6.733. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Webster L. T., Clow A. D. INTRANASAL VIRULENCE OF PNEUMOCOCCI FOR MICE. J Exp Med. 1933 Sep 30;58(4):465–483. doi: 10.1084/jem.58.4.465. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Webster L. T. INHERITED AND ACQUIRED FACTORS IN RESISTANCE TO INFECTION : II. A COMPARISON OF MICE INHERENTLY RESISTANT OR SUSCEPTIBLE TO BACILLUS ENTERITIDIS INFECTION WITH RESPECT TO FERTILITY, WEIGHT, AND SUSCEPTIBILITY TO VARIOUS ROUTES AND TYPES OF INFECTION. J Exp Med. 1933 Apr 30;57(5):819–843. doi: 10.1084/jem.57.5.819. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES