Abstract
The phenomena observed on absorption of immune sera to azoproteins with heterologous azoantigens lead to the conclusion that in general the sera do not contain a single antibody but antibody fractions somewhat different in their reactivity for heterologous antigens. From the constitution of the azocomponent it follows that these fractions cannot be specific for distinct chemical groups in the molecule. In fact, inhibition experiments showed that in the cases examined the various antibodies are all specifically directed towards the whole molecule of the homologous hapten.
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Selected References
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- Heidelberger M., Kendall F. E. A QUANTITATIVE THEORY OF THE PRECIPITIN REACTION : III. THE REACTION BETWEEN CRYSTALLINE EGG ALBUMIN AND ITS HOMOLOGOUS ANTIBODY. J Exp Med. 1935 Oct 31;62(5):697–720. doi: 10.1084/jem.62.5.697. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Landsteiner K., van der Scheer J. ON THE SEROLOGICAL SPECIFICITY OF PEPTIDES. II. J Exp Med. 1934 May 31;59(6):769–780. doi: 10.1084/jem.59.6.769. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Landsteiner K., van der Scheer J. ON THE SPECIFICITY OF AGGLUTININS AND PRECIPITINS. J Exp Med. 1924 Jun 30;40(1):91–107. doi: 10.1084/jem.40.1.91. [DOI] [PMC free article] [PubMed] [Google Scholar]
