Abstract
The results of mouse protection tests with 136 human sera and a strain of human influenza virus are described. After the 1st year of life, the sera of approximately half the individuals tested contained sufficient antibody to furnish complete protection to mice. A much higher percentage of the sera obtained from individuals recently convalescent from influenza exerted a completely protective effect. On the other hand, certain sera protected only partially under the conditions of the tests. The results have been compared with those obtained by Shope in tests done with the same sera against swine influenza virus. The possible epidemiological significance of the results is discussed.
Full Text
The Full Text of this article is available as a PDF (837.1 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Francis T., Jr TRANSMISSION OF INFLUENZA BY A FILTERABLE VIRUS. Science. 1934 Nov 16;80(2081):457–459. doi: 10.1126/science.80.2081.457-a. [DOI] [PubMed] [Google Scholar]
- Francis T., Magill T. P. IMMUNOLOGICAL STUDIES WITH THE VIRUS OF INFLUENZA. J Exp Med. 1935 Sep 30;62(4):505–516. doi: 10.1084/jem.62.4.505. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Francis T., Shope R. E. NEUTRALIZATION TESTS WITH SERA OF CONVALESCENT OR IMMUNIZED ANIMALS AND THE VIRUSES OF SWINE AND HUMAN INFLUENZA. J Exp Med. 1936 Apr 30;63(5):645–653. doi: 10.1084/jem.63.5.645. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Paul J. R., Trask J. D. THE NEUTRALIZATION TEST IN POLIOMYELITIS : COMPARATIVE RESULTS WITH FOUR STRAINS OF THE VIRUS. J Exp Med. 1935 Mar 31;61(4):447–464. doi: 10.1084/jem.61.4.447. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shope R. E. THE INCIDENCE OF NEUTRALIZING ANTIBODIES FOR SWINE INFLUENZA VIRUS IN THE SERA OF HUMAN BEINGS OF DIFFERENT AGES. J Exp Med. 1936 Apr 30;63(5):669–684. doi: 10.1084/jem.63.5.669. [DOI] [PMC free article] [PubMed] [Google Scholar]