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The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1936 Jun 30;64(1):79–96. doi: 10.1084/jem.64.1.79

SEROLOGICAL REACTIONS WITH A VIRUS CAUSING RABBIT PAPILLOMAS WHICH BECOME CANCEROUS

II. TESTS OF THE BLOOD OF ANIMALS CARRYING VARIOUS EPITHELIAL TUMORS

John G Kidd 1, J W Beard 1, Peyton Rous 1
PMCID: PMC2133416  PMID: 19870525

Abstract

The serum of a rabbit with large cancers resulting from the transplantation of a squamous cell carcinoma that had arisen from a virusinduced papilloma, possessed the power to neutralize the virus, and so too in less degree did that of an animal of the same transplantation series in which a small nodule had developed. The sera of rabbits carrying tar papillomas or the Brown-Pearce carcinoma proved wholly devoid of effect on the virus. The implantation of Brown-Pearce tumor material mixed with virus did not lead to an enduring establishment of the latter in the resulting growths, nor to any immediate changes in their morphological character. The significance of the facts is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brown W. H., Pearce L. STUDIES BASED ON A MALIGNANT TUMOR OF THE RABBIT : I. THE SPONTANEOUS TUMOR AND ASSOCIATED ABNORMALITIES. J Exp Med. 1923 Apr 30;37(5):601–629. doi: 10.1084/jem.37.5.601. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Rivers T. M., Pearce L. GROWTH AND PERSISTENCE OF FILTERABLE VIRUSES IN A TRANSPLANTABLE RABBIT NEOPLASM. J Exp Med. 1925 Sep 30;42(4):523–537. doi: 10.1084/jem.42.4.523. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Rous P., Beard J. W. A VIRUS-INDUCED MAMMALIAN GROWTH WITH THE CHARACTERS OF A TUMOR (THE SHOPE RABBIT PAPILLOMA) : III. FURTHER CHARACTERS OF THE GROWTH: GENERAL DISCUSSION. J Exp Med. 1934 Nov 30;60(6):741–766. doi: 10.1084/jem.60.6.741. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Rous P., Beard J. W. THE PROGRESSION TO CARCINOMA OF VIRUS-INDUCED RABBIT PAPILLOMAS (SHOPE). J Exp Med. 1935 Sep 30;62(4):523–548. doi: 10.1084/jem.62.4.523. [DOI] [PMC free article] [PubMed] [Google Scholar]

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