Abstract
1. Guinea pigs can be actively immunized against European typhus fever with homologous formalinized Rickettsia tissue cultures, provided sufficient amounts are injected. The method is suggested for practical application in man. 2. Serovaccination against European typhus fever can be successfully applied to guinea pigs by a variety of methods, the simplest of which consists of the injection of mixtures of virulent defibrinated guinea pig blood and convalescent guinea pig serum taken from 3 to 5 days after defervescence. Similar results can be obtained with mixtures in which tissue culture virus, either with convalescent guinea pig serum or with antimurine horse serum, is used. There is no indication so far that such animals become carriers. Possible application of these methods to typhus epidemics is discussed.
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Selected References
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- Nigg C., Landsteiner K. STUDIES ON THE CULTIVATION OF THE TYPHUS FEVER RICKETTSIA IN THE PRESENCE OF LIVE TISSUE. J Exp Med. 1932 Mar 31;55(4):563–576. doi: 10.1084/jem.55.4.563. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sawyer W. A., Kitchen S. F., Lloyd W. VACCINATION AGAINST YELLOW FEVER WITH IMMUNE SERUM AND VIRUS FIXED FOR MICE. J Exp Med. 1932 May 31;55(6):945–969. doi: 10.1084/jem.55.6.945. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zinsser H., Batchelder A. P. STUDIES ON MEXICAN TYPHUS FEVER. I. J Exp Med. 1930 May 31;51(6):847–858. doi: 10.1084/jem.51.6.847. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zinsser H., Castaneda M. R. STUDIES ON TYPHUS FEVER : IX. ON THE SERUM REACTIONS OF MEXICAN AND EUROPEAN TYPHUS RICKETTSIA. J Exp Med. 1932 Sep 30;56(4):455–467. doi: 10.1084/jem.56.4.455. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zinsser H., Castaneda M. R. STUDIES ON TYPHUS FEVER : X. FURTHER EXPERIMENTS ON ACTIVE IMMUNIZATION AGAINST TYPHUS FEVER WITH KILLED RICKETTSIA. J Exp Med. 1933 Feb 28;57(3):381–390. doi: 10.1084/jem.57.3.381. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zinsser H., Castaneda M. R. STUDIES ON TYPHUS FEVER : XII. THE PASSIVE IMMUNIZATION OF GUINEA PIGS, INFECTED WITH EUROPEAN VIRUS, WITH SERUM OF A HORSE TREATED WITH KILLED RICKETTSIA OF THE MEXICAN TYPE. J Exp Med. 1934 Mar 31;59(4):471–478. doi: 10.1084/jem.59.4.471. [DOI] [PMC free article] [PubMed] [Google Scholar]