Abstract
Vital dyes injected intradermally enter lymphatic capillaries directly, rendering them visible, and appear later in the draining lymphatic trunks as colored streamers. The method enables one to perceive the state of the lymphatic channels and the rate of lymph flow within them. It yields consistent results when tested under physiological conditions known to increase or decrease lymph flow. In the horizontally placed normal limb at rest there is slight lymph flow. In a normal leg or arm hanging downward lymph flow ceases although fluid in the limb increases. When a previously dependent arm is raised above the head, or when the foot of a seated subject is propped on a table, lymph flow in the raised limb becomes active. It ceases in the skin of an arm subjected to partial obstruction of the veins by pressure from without, but very active lymph flow appears during the reactive hyperemia which follows upon the release of venous obstruction. It is still greater following release of total circulatory obstruction, and seems to be the same whether or not the limb has previously been engorged with blood. In the ischemic patches which appear in the skin of a limb during total circulatory obstruction (Bier's spots) the lymphatic capillaries are definitely and considerably constricted, whereas they are slightly dilated in the purple, congested regions of the skin round about. On release of obstruction there occurs a strikingly rapid, equal lymphatic drainage from both regions. The significance of all the findings is discussed. When dye is injected intradermally and the skin sucked, much of the foreign material is driven into the lymphatics draining the injected area.
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Selected References
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- Bainbridge F. A. Observations on the lymph flow from the submaxillary gland of the dog. J Physiol. 1900 Dec 31;26(1-2):79–91. doi: 10.1113/jphysiol.1900.sp000823. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Field M. E., Drinker C. K., White J. C. LYMPH PRESSURES IN STERILE INFLAMMATION. J Exp Med. 1932 Aug 31;56(3):363–370. doi: 10.1084/jem.56.3.363. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hudack S. S., McMaster P. D. THE LYMPHATIC PARTICIPATION IN HUMAN CUTANEOUS PHENOMENA : A STUDY OF THE MINUTE LYMPHATICS OF THE LIVING SKIN. J Exp Med. 1933 Apr 30;57(5):751–774. doi: 10.1084/jem.57.5.751. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hudack S., McMaster P. D. THE GRADIENT OF PERMEABILITY OF THE SKIN VESSELS AS INFLUENCED BY HEAT, COLD, AND LIGHT. J Exp Med. 1932 Feb 29;55(3):431–439. doi: 10.1084/jem.55.3.431. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Landis E. M., Gibbon J. H. THE EFFECTS OF TEMPERATURE AND OF TISSUE PRESSURE ON THE MOVEMENT OF FLUID THROUGH THE HUMAN CAPILLARY WALL. J Clin Invest. 1933 Jan;12(1):105–138. doi: 10.1172/JCI100482. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rous P., Gilding H. P. THE FINAL RESPONSE OF THE SMALL CUTANEOUS VESSELS. J Exp Med. 1929 Sep 30;50(4):489–512. doi: 10.1084/jem.50.4.489. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Starling E. H. The Influence of Mechanical Factors on Lymph Production. J Physiol. 1894 Apr 17;16(3-4):224–267. doi: 10.1113/jphysiol.1894.sp000500. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Thompson W. O., Thompson P. K., Dailey M. E. THE EFFECT OF POSTURE UPON THE COMPOSITION AND VOLUME OF THE BLOOD IN MAN. J Clin Invest. 1928 Jun;5(4):573–604. doi: 10.1172/JCI100179. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Waterfield R. L. The effects of posture on the circulating blood volume. J Physiol. 1931 Jun 6;72(1):110–120. doi: 10.1113/jphysiol.1931.sp002765. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Weech A. A., Goettsch E., Reeves E. B. THE FLOW AND COMPOSITION OF LYMPH IN RELATION TO THE FORMATION OF EDEMA. J Exp Med. 1934 Jun 30;60(1):63–84. doi: 10.1084/jem.60.1.63. [DOI] [PMC free article] [PubMed] [Google Scholar]