Skip to main content
The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1937 Mar 31;65(4):487–496. doi: 10.1084/jem.65.4.487

A QUANTITATIVE STUDY OF THE CROSS REACTION OF TYPES III AND VIII PNEUMOCOCCI IN HORSE AND RABBIT ANTISERA

Michael Heidelberger 1, Elvin A Kabat 1, D L Shrivastava 1
PMCID: PMC2133500  PMID: 19870613

Abstract

1. A preparation of the specific polysaccharide of Type VIII pneumococcus is described in which the use of heat, strong acid, and alkali were avoided. 2. Quantitative estimations are given of the homologous and cross reacting precipitin and agglutinin in Types III and VIII antisera produced in the rabbit and in the horse. Quantitative data are also given on the mechanism of the Type VIII precipitin reaction and the cross reaction between the Type III polysaccharide and Type VIII antipneumococcus horse serum. 3. The significance of the data is discussed.

Full Text

The Full Text of this article is available as a PDF (451.3 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Avery O. T., Goebel W. F. CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : II. IMMUNOLOGICAL SPECIFICITY OF SYNTHETIC SUGAR-PROTEIN ANTIGENS. J Exp Med. 1929 Sep 30;50(4):533–550. doi: 10.1084/jem.50.4.533. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Avery O. T., Heidelberger M., Goebel W. F. THE SOLUBLE SPECIFIC SUBSTANCE OF FRIEDLANDER'S BACILLUS : PAPER II. CHEMICAL AND IMMUNOLOGICAL RELATIONSHIPS OF PNEUMOCOCCUS TYPE II AND OF A STRAIN OF FRIEDLANDER'S BACILLUS. J Exp Med. 1925 Oct 31;42(5):709–725. doi: 10.1084/jem.42.5.709. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Chow B. F. IMMUNOLOGICAL STUDIES ON A NEW PREPARATION OF TYPE SPECIFIC POLYSACCHARIDE FROM PNEUMOCOCCUS TYPE I. J Exp Med. 1936 Nov 30;64(6):843–854. doi: 10.1084/jem.64.6.843. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cooper G., Edwards M., Rosenstein C. THE SEPARATION OF TYPES AMONG THE PNEUMOCOCCI HITHERTO CALLED GROUP IV AND THE DEVELOPMENT OF THERAPEUTIC ANTISERUMS FOR THESE TYPES. J Exp Med. 1929 Feb 28;49(3):461–474. doi: 10.1084/jem.49.3.461. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Heidelberger M., Kabat E. A. CHEMICAL STUDIES ON BACTERIAL AGGLUTINATION : I. A METHOD. J Exp Med. 1934 Oct 31;60(5):643–653. doi: 10.1084/jem.60.5.643. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Heidelberger M., Kabat E. A. CHEMICAL STUDIES ON BACTERIAL AGGLUTINATION : II. THE IDENTITY OF PRECIPITIN AND AGGLUTININ. J Exp Med. 1936 Apr 30;63(5):737–744. doi: 10.1084/jem.63.5.737. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Heidelberger M., Kendall F. E. QUANTITATIVE STUDIES ON THE PRECIPITIN REACTION : THE ROLE OF MULTIPLE REACTIVE GROUPS IN ANTIGEN-ANTIBODY UNION AS ILLUSTRATED BY AN INSTANCE OF CROSS-PRECIPITATION. J Exp Med. 1934 Mar 31;59(4):519–528. doi: 10.1084/jem.59.4.519. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Heidelberger M., Kendall F. E., Scherp H. W. THE SPECIFIC POLYSACCHARIDES OF TYPES I, II, AND III PNEUMOCOCCUS : A REVISION OF METHODS AND DATA. J Exp Med. 1936 Sep 30;64(4):559–572. doi: 10.1084/jem.64.4.559. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Heidelberger M., Kendall F. E., Soo Hoo C. M. QUANTITATIVE STUDIES ON THE PRECIPITIN REACTION : ANTIBODY PRODUCTION IN RABBITS INJECTED WITH AN AZO PROTEIN. J Exp Med. 1933 Jul 31;58(2):137–152. doi: 10.1084/jem.58.2.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Heidelberger M., Kendall F. E. THE PRECIPITIN REACTION BETWEEN TYPE III PNEUMOCOCCUS POLYSACCHARIDE AND HOMOLOGOUS ANTIBODY : II. CONDITIONS FOR QUANTITATIVE PRECIPITATION OF ANTIBODY IN HORSE SERA. J Exp Med. 1935 Mar 31;61(4):559–562. doi: 10.1084/jem.61.4.559. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Heidelberger M., Kendall F. E. THE PRECIPITIN REACTION BETWEEN TYPE III PNEUMOCOCCUS POLYSACCHARIDE AND HOMOLOGOUS ANTIBODY : III. A QUANTITATIVE STUDY AND A THEORY OF THE REACTION MECHANISM. J Exp Med. 1935 Mar 31;61(4):563–591. doi: 10.1084/jem.61.4.563. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Sugg J. Y., Gaspari E. L., Fleming W. L., Neill J. M. STUDIES ON IMMUNOLOGICAL RELATIONSHIPS AMONG THE PNEUMOCOCCI : I. A VIRULENT STRAIN OF PNEUMOCOCCUS WHICH Is IMMUNOLOGICALLY RELATED TO, BUT NOT IDENTICAL WITH TYPICAL STRAINS OF TYPE III PNEUMOCOCCI. J Exp Med. 1928 May 31;47(6):917–931. doi: 10.1084/jem.47.6.917. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES