Skip to main content
PMC home page
The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1937 Apr 30;65(5):647–660. doi: 10.1084/jem.65.5.647

A QUANTITATIVE THEORY OF THE PRECIPITIN REACTION

IV. THE REACTION OF PNEUMOCOCCUS SPECIFIC POLYSACCHARIDES WITH HOMOLOGOUS RABBIT ANTISERA

Michael Heidelberger 1, Forrest E Kendall 1
PMCID: PMC2133513  PMID: 19870624

Abstract

1. The reaction between the specific polysaccharide of Type III pneumococcus and homologous antibody in rabbit sera is quantitatively accounted for by expressions similar to those derived from the mass law for the corresponding horse sera. Preliminary data are also given for the Type I reaction. 2. Differences and similarities of the reaction with antibodies produced by the two animals are discussed. 3. Calculations are made of the equivalent composition of the specific precipitate at various reference points in the reaction range. 4. Certain theoretical and practical implications of the findings are pointed out.

Full Text

The Full Text of this article is available as a PDF (648.2 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Avery O. T., Goebel W. F. CHEMOIMMUNOLOGICAL STUDIES ON THE SOLUBLE SPECIFIC SUBSTANCE OF PNEUMOCOCCUS : I. THE ISOLATION AND PROPERTIES OF THE ACETYL POLYSACCHARIDE OF PNEUMOCOCCUS TYPE I. J Exp Med. 1933 Nov 30;58(6):731–755. doi: 10.1084/jem.58.6.731. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Heidelberger M., Goebel W. F., Avery O. T. THE SOLUBLE SPECIFIC SUBSTANCE OF PNEUMOCOCCUS : THIRD PAPER. J Exp Med. 1925 Oct 31;42(5):727–745. doi: 10.1084/jem.42.5.727. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Heidelberger M., Kendall F. E. A QUANTITATIVE STUDY OF THE PRECIPITIN REACTION BETWEEN TYPE III PNEUMOCOCCUS POLYSACCHARIDE AND PURIFIED HOMOLOGOUS ANTIBODY. J Exp Med. 1929 Nov 30;50(6):809–823. doi: 10.1084/jem.50.6.809. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Heidelberger M., Kendall F. E. A QUANTITATIVE THEORY OF THE PRECIPITIN REACTION : II. A STUDY OF AN AZOPROTEIN-ANTIBODY SYSTEM. J Exp Med. 1935 Sep 30;62(4):467–483. doi: 10.1084/jem.62.4.467. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Heidelberger M., Kendall F. E. A QUANTITATIVE THEORY OF THE PRECIPITIN REACTION : III. THE REACTION BETWEEN CRYSTALLINE EGG ALBUMIN AND ITS HOMOLOGOUS ANTIBODY. J Exp Med. 1935 Oct 31;62(5):697–720. doi: 10.1084/jem.62.5.697. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Heidelberger M., Kendall F. E. QUANTITATIVE STUDIES ON ANTIBODY PURIFICATION : I. THE DISSOCIATION OF PRECIPITATES FORMED BY PNEUMOCOCCUS SPECIFIC POLYSACCHARIDES AND HOMOLOGOUS ANTIBODIES. J Exp Med. 1936 Jul 31;64(2):161–172. doi: 10.1084/jem.64.2.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Heidelberger M., Kendall F. E. QUANTITATIVE STUDIES ON THE PRECIPITIN REACTION : THE DETERMINATION OF SMALL AMOUNTS OF A SPECIFIC POLYSACCHARIDE. J Exp Med. 1932 Mar 31;55(4):555–561. doi: 10.1084/jem.55.4.555. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Heidelberger M., Kendall F. E. SPECIFIC AND NON-SPECIFIC POLYSACCHARIDES OF TYPE IV PNEUMOCOCCUS. J Exp Med. 1931 Apr 30;53(5):625–639. doi: 10.1084/jem.53.5.625. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Heidelberger M., Kendall F. E. STUDIES ON THE PRECIPITIN REACTION : PRECIPITATING HAPTENS; SPECIES DIFFERENCES IN ANTIBODIES. J Exp Med. 1933 Feb 28;57(3):373–379. doi: 10.1084/jem.57.3.373. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Heidelberger M., Kendall F. E., Scherp H. W. THE SPECIFIC POLYSACCHARIDES OF TYPES I, II, AND III PNEUMOCOCCUS : A REVISION OF METHODS AND DATA. J Exp Med. 1936 Sep 30;64(4):559–572. doi: 10.1084/jem.64.4.559. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Heidelberger M., Kendall F. E., Soo Hoo C. M. QUANTITATIVE STUDIES ON THE PRECIPITIN REACTION : ANTIBODY PRODUCTION IN RABBITS INJECTED WITH AN AZO PROTEIN. J Exp Med. 1933 Jul 31;58(2):137–152. doi: 10.1084/jem.58.2.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Heidelberger M., Kendall F. E. THE PRECIPITIN REACTION BETWEEN TYPE III PNEUMOCOCCUS POLYSACCHARIDE AND HOMOLOGOUS ANTIBODY : II. CONDITIONS FOR QUANTITATIVE PRECIPITATION OF ANTIBODY IN HORSE SERA. J Exp Med. 1935 Mar 31;61(4):559–562. doi: 10.1084/jem.61.4.559. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Heidelberger M., Kendall F. E. THE PRECIPITIN REACTION BETWEEN TYPE III PNEUMOCOCCUS POLYSACCHARIDE AND HOMOLOGOUS ANTIBODY : III. A QUANTITATIVE STUDY AND A THEORY OF THE REACTION MECHANISM. J Exp Med. 1935 Mar 31;61(4):563–591. doi: 10.1084/jem.61.4.563. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Heidelberger M., Kendall F. E., Teorell T. QUANTITATIVE STUDIES ON THE PRECIPITIN REACTION : EFFECT OF SALTS ON THE REACTION. J Exp Med. 1936 May 31;63(6):819–826. doi: 10.1084/jem.63.6.819. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Heidelberger M., Pedersen K. O. THE MOLECULAR WEIGHT OF ANTIBODIES. J Exp Med. 1937 Feb 28;65(3):393–414. doi: 10.1084/jem.65.3.393. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Horsfall F. L., Jr, Goodner K., Macleod C. M. TYPE SPECIFIC ANTIPNEUMOCOCCUS RABBIT SERUM. Science. 1936 Dec 25;84(2191):579–581. doi: 10.1126/science.84.2191.579. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES