Abstract
An experimental analysis of the factors responsible for the observed differences in the course of virus-induced papillomas of the rabbit has shown that some are referable to the virus, others to the cells, and yet others to host influences. The interplay of these factors affords enlightening illustration of the nature of the cell-virus relationship in virus-induced tumors. Retrogression of the rabbit papillomas appears to be consequent on a generalized resistance of host origin, elicited by and directed against the proliferating, virus-infected cells.
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Selected References
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- Rous P., Beard J. W. A VIRUS-INDUCED MAMMALIAN GROWTH WITH THE CHARACTERS OF A TUMOR (THE SHOPE RABBIT PAPILLOMA) : I. THE GROWTH ON IMPLANTATION WITHIN FAVORABLE HOSTS. J Exp Med. 1934 Nov 30;60(6):701–722. doi: 10.1084/jem.60.6.701. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rous P., Kidd J. G., Beard J. W. OBSERVATIONS ON THE RELATION OF THE VIRUS CAUSING RABBIT PAPILLOMAS TO THE CANCERS DERIVING THEREFROM : I. THE INFLUENCE OF THE HOST SPECIES AND OF THE PATHOGENIC ACTIVITY AND CONCENTRATION OF THE VIRUS. J Exp Med. 1936 Aug 31;64(3):385–400. doi: 10.1084/jem.64.3.385. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rous P., McMaster P. D., Hudack S. S. THE FIXATION AND PROTECTION OF VIRUSES BY THE CELLS OF SUSCEPTIBLE ANIMALS. J Exp Med. 1935 Apr 30;61(5):657–688. doi: 10.1084/jem.61.5.657. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rous P., Murphy J. B. ON IMMUNITY TO TRANSPLANTABLE CHICKEN TUMORS. J Exp Med. 1914 Oct 1;20(4):419–432. doi: 10.1084/jem.20.4.419. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shope R. E., Hurst E. W. INFECTIOUS PAPILLOMATOSIS OF RABBITS : WITH A NOTE ON THE HISTOPATHOLOGY. J Exp Med. 1933 Oct 31;58(5):607–624. doi: 10.1084/jem.58.5.607. [DOI] [PMC free article] [PubMed] [Google Scholar]
