Abstract
1. The injection of leech extracts into the skin increases its permeability, as shown both by the spread of fluid and of foreign particles through the dermis. The spread is followed some hours after the injection by more or less edema of the subcutaneous tissue. 2. A preliminary study of the chemical properties of the leech spreading factor indicates a similarity with the spreading factor prepared from testicle. 3. Attempts to separate the leech spreading and anticoagulating factors showed that the two have practically the same distribution in the leech body, extracts from the separated head being the most active. 4. It is undetermined whether two distinct factors are responsible for the spreading and anticoagulating properties of leech extracts. A chemical similarity is suggested by the fact that agents which affect the activity of one factor have a parallel effect on the other. 5. The mechanism of the spread produced by leech extracts and by other spreading agents is discussed.
Full Text
The Full Text of this article is available as a PDF (729.9 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Claude A. A GROUP OF CHEMICALS ACTIVE IN INCREASING TISSUE PERMEABILITY AND ENHANCING CERTAIN INFECTIOUS PROCESSES. Science. 1933 Aug 18;78(2016):151–152. doi: 10.1126/science.78.2016.151. [DOI] [PubMed] [Google Scholar]
- Claude A., Duran-Reynals F. CHEMICAL PROPERTIES OF THE PURIFIED SPREADING FACTOR FROM TESTICLE. J Exp Med. 1937 Apr 30;65(5):661–670. doi: 10.1084/jem.65.5.661. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Claude A. SPREADING PROPERTY OF AZOPROTEINS IN THE DERMIS. J Exp Med. 1935 Jul 31;62(2):229–244. doi: 10.1084/jem.62.2.229. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hoffman D. C., Duran-Reynals F. THE MECHANISM OF ENHANCEMENT OF INFECTIONS BY TESTICLE EXTRACT. Science. 1930 Nov 14;72(1872):508–508. doi: 10.1126/science.72.1872.508. [DOI] [PubMed] [Google Scholar]