Abstract
A study has been made of the nasal histology in normal ferrets and in ferrets during and after infection with epidemic influenza virus. During the acute stage of infection the respiratory epithelium of the nasal mucous membrane undergoes necrosis with desquamation of the superficial cells and exudation into the air passages, and an inflammatory reaction occurs in the submucosa. Repair begins on the 4th day after infection, and from the 6th to the 14th day the respiratory area is covered successively by a transitional, a stratified squamous, and finally a stratified columnar epithelium. By the 21st day after infection the epithelium has been largely restored to normal but repair in the submucosa and cartilage is still in progress. The respiratory mucosa is substantially normal in structure 1 month after infection although minor abnormalities of cellular arrangement and type can still be distinguished.
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Selected References
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- Francis T., Magill T. P. IMMUNOLOGICAL STUDIES WITH THE VIRUS OF INFLUENZA. J Exp Med. 1935 Sep 30;62(4):505–516. doi: 10.1084/jem.62.4.505. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Francis T., Magill T. P., Rickard E. R., Beck M. D. Etiological and Serological Studies in Epidemic Influenza. Am J Public Health Nations Health. 1937 Nov;27(11):1141–1160. doi: 10.2105/ajph.27.11.1141. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Francis T., Shope R. E. NEUTRALIZATION TESTS WITH SERA OF CONVALESCENT OR IMMUNIZED ANIMALS AND THE VIRUSES OF SWINE AND HUMAN INFLUENZA. J Exp Med. 1936 Apr 30;63(5):645–653. doi: 10.1084/jem.63.5.645. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hoyle L., Fairbrother R. W. Isolation of Influenza Virus: The Manchester Epidemic. Br Med J. 1937 Mar 27;1(3977):655–657. doi: 10.1136/bmj.1.3977.655. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Macnider W. D. THE DEVELOPMENT OF THE CHRONIC NEPHRITIS INDUCED IN THE DOG BY URANIUM NITRATE. A FUNCTIONAL AND PATHOLOGICAL STUDY WITH OBSERVATIONS ON THE FORMATION OF URINE BY THE ALTERED KIDNEYS. J Exp Med. 1929 Feb 28;49(3):387–410. doi: 10.1084/jem.49.3.387. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Macnider W. D. THE FUNCTIONAL AND PATHOLOGICAL RESPONSE OF THE KIDNEY IN DOGS SUBJECTED TO A SECOND SUBCUTANEOUS INJECTION OF URANIUM NITRATE. J Exp Med. 1929 Feb 28;49(3):411–433. doi: 10.1084/jem.49.3.411. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shope R. E., Francis T. THE SUSCEPTIBILITY OF SWINE TO THE VIRUS OF HUMAN INFLUENZA. J Exp Med. 1936 Oct 31;64(5):791–801. doi: 10.1084/jem.64.5.791. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shope R. E. IMMUNIZATION EXPERIMENTS WITH SWINE INFLUENZA VIRUS. J Exp Med. 1936 Jun 30;64(1):47–61. doi: 10.1084/jem.64.1.47. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shope R. E. SWINE INFLUENZA : III. FILTRATION EXPERIMENTS AND ETIOLOGY. J Exp Med. 1931 Jul 31;54(3):373–385. doi: 10.1084/jem.54.3.373. [DOI] [PMC free article] [PubMed] [Google Scholar]