Abstract
After inoculation with equine encephalomyelitis virus by various routes, guinea pigs were sacrificed at early stages, before symptoms were apparent. The brains were studied histologically, with serial sections; all lesions were noted, and subjected to topographical analysis. Nine cases are presented in detail. With any given mode of inoculation the distribution of lesions varied very widely from one instance to another. In some cases, affected regions bore a striking and definite anatomical relationship to each other. These distributions can be explained only by the assumption that the anatomical pathways played some rôle in the spread of the virus. In other instances lesions were present in areas, the anatomical connections of which were entirely normal. Attention is called to the frequency of lesions in the neocortex, with intact subcortical centers. Such distribution is held to render nerve spread extremely improbable. The only satisfactory explanation of such random distributions is by direct passage of virus from the blood stream into the brain tissue. There is no histological difference between lesions which result from blood spread and those resulting from nerve spread.
Full Text
The Full Text of this article is available as a PDF (1.1 MB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Goodpasture E. W., Teague O. Transmission of the Virus of Herpes Febrilis along Nerves in experimentally infected Rabbits. J Med Res. 1923 Dec;44(2):139–184.7. [PMC free article] [PubMed] [Google Scholar]
- King L. S. STUDIES ON EASTERN EQUINE ENCEPHALOMYELITIS : I. HISTOPATHOLOGY OF THE NERVOUS SYSTEM IN THE GUINEA PIG. J Exp Med. 1938 Oct 31;68(5):677–692. doi: 10.1084/jem.68.5.677. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Larsell O., Haring C. M., Meyer K. F. Histological Changes in the Central Nervous System Following Equine Encephalomyelitis. Am J Pathol. 1934 May;10(3):361–374.3. doi: 10.1097/00005053-193501000-00028. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McClellan R. H., Goodpasture E. W. A Method of Demonstrating Experimental Gross Lesions of the Central Nervous System. J Med Res. 1923 Dec;44(2):201–206.1. [PMC free article] [PubMed] [Google Scholar]
- Sabin A. B., Olitsky P. K. INFLUENCE OF HOST FACTORS ON NEUROINVASIVENESS OF VESICULAR STOMATITIS VIRUS : III. EFFECT OF AGE AND PATHWAY OF INFECTION ON THE CHARACTER AND LOCALIZATION OF LESIONS IN THE CENTRAL NERVOUS SYSTEM. J Exp Med. 1938 Jan 31;67(2):201–228. doi: 10.1084/jem.67.2.201. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Yoffey J. M., Drinker C. K. THE LYMPHATIC PATHWAY FROM THE NOSE AND PHARYNX : THE ABSORPTION OF DYES. J Exp Med. 1938 Sep 30;68(4):629–640. doi: 10.1084/jem.68.4.629. [DOI] [PMC free article] [PubMed] [Google Scholar]