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. 1981 Jun;86(3):303–313. doi: 10.1017/s0022172400069059

Infection with influenza A/Victoria virus in Houston families, 1976.

L H Taber, A Paredes, W P Glezen, R B Couch
PMCID: PMC2133985  PMID: 7016989

Abstract

In 1976, an epidemic caused by infections with an influenza virus antigenically similar to A/Victoria/75 (H3N2) occurred in Houston, Texas. During this outbreak, 37 families (155 members) enrolled in the Houston Family Study were under observation. The families lived throughout the metropolitan area (Houston, Texas), and were representative of low income groups. The overall frequency of infection in family members was 27.7%. The frequency of infection was the highest for infants under one year of age and for their older siblings, 14 (37.8%) of 37 and 17 (33.3%) of 51, respectively. Eighteen (48.6%) of the 37 families had at least one infected member. Twelve of the 18 'infected' families had school aged children, whereas only three of the 19 'non-infected' families had school aged children (P less than 0.01). These infected families were also larger and had increased household density (persons/rooms). The levels of pre-existing HI antibodies to A/Victoria/75 and A/Port Chalmers/73 were inversely related to frequencies of infection and illness associated with A/Victoria/75 virus. Three children required hospitalization as direct consequence of their infection with this H3N2 influenza virus. Antibody response to infection was related to previous experience with antigenically-related influenza A (H3N2) viruses according to Francis', 'doctrine of original antigenic sin.'

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baxter B. D., Couch R. B., Greenberg S. B., Kasel J. A. Maintenance of viability and comparison of identification methods for influenza and other respiratory viruses of humans. J Clin Microbiol. 1977 Jul;6(1):19–22. doi: 10.1128/jcm.6.1.19-22.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. DAVENPORT F. M., HENNESSY A. V., BERNSTEIN S. H., HARPER O. F., Jr, KLINGENSMITH W. H. Comparative incidence of influenza A-prime in 1953 in completely vaccinated and unvaccinated military groups. Am J Public Health Nations Health. 1955 Sep;45(9):1138–1146. doi: 10.2105/ajph.45.9.1138. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DUNN F. L., CAREY D. E., COHEN A., MARTIN J. D. Epidemiologic studies of Asian influenza in a Louisiana parish. Am J Hyg. 1959 Nov;70:351–371. doi: 10.1093/oxfordjournals.aje.a120083. [DOI] [PubMed] [Google Scholar]
  4. FRANCIS T., Jr The current status of the control of influenza. Ann Intern Med. 1955 Sep;43(3):534–538. doi: 10.7326/0003-4819-43-3-534. [DOI] [PubMed] [Google Scholar]
  5. Farník J., Bruj J. An outbreak of influenza A2 in a population with a known antibody profile. J Infect Dis. 1966 Oct;116(4):425–428. doi: 10.1093/infdis/116.4.425. [DOI] [PubMed] [Google Scholar]
  6. Galbraith A. W., Oxford J. S., Schild G. C., Watson G. I. Protective effect of 1-adamantanamine hydrochloride on influenza A2 infections in the family environment: a controlled double-blind study. Lancet. 1969 Nov 15;2(7629):1026–1028. doi: 10.1016/s0140-6736(69)90639-4. [DOI] [PubMed] [Google Scholar]
  7. Galbraith A. W., Oxford J. S., Schild G. C., Watson G. I. Study of 1-adamantanamine hydrochloride used prophylactically during the Hong Kong influenza epidemic in the family environment. Bull World Health Organ. 1969;41(3):677–682. [PMC free article] [PubMed] [Google Scholar]
  8. Glezen W. P., Couch R. B. Interpandemic influenza in the Houston area, 1974-76. N Engl J Med. 1978 Mar 16;298(11):587–592. doi: 10.1056/NEJM197803162981103. [DOI] [PubMed] [Google Scholar]
  9. Glezen W. P., Paredes A., Taber L. H. Influenza in children. Relationship to other respiratory agents. JAMA. 1980 Apr 4;243(13):1345–1349. doi: 10.1001/jama.243.13.1345. [DOI] [PubMed] [Google Scholar]
  10. Greenberg S. B., Couch R. B., Kasel J. A. An outbreak of an influenza type A variant in a closed population: The effect of homologous and heterologous antibody on infection and illness. Am J Epidemiol. 1974 Sep;100(3):209–215. doi: 10.1093/oxfordjournals.aje.a112029. [DOI] [PubMed] [Google Scholar]
  11. Hall C. B., Douglas R. G., Jr Clinically useful method for the isolation of respiratory syncytial virus. J Infect Dis. 1975 Jan;131(1):1–5. doi: 10.1093/infdis/131.1.1. [DOI] [PubMed] [Google Scholar]
  12. Hope-Simpson R. E. First outbreak of Hong Kong influenza in a general practice population in Great Britain. A field and laboratory study. Br Med J. 1970 Jul 11;3(5714):74–77. doi: 10.1136/bmj.3.5714.74. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. JORDAN W. S., Jr, DENNY F. W., Jr, BADGER G. F., CURTISS C., DINGLE J. H., OSEASOHN R., STEVENS D. A. A study of illness in a group of Cleveland families. XVII. The occurrence of Asian influenza. Am J Hyg. 1958 Sep;68(2):190–212. doi: 10.1093/oxfordjournals.aje.a119962. [DOI] [PubMed] [Google Scholar]
  14. Jennings L. C., Miles J. A. A study of acute respiratory disease in the community of Port Chalmers. II. Influenza A/Port Chalmers/1/73: intrafamilial spread and the effect of antibodies to the surface antigens. J Hyg (Lond) 1978 Aug;81(1):67–75. doi: 10.1017/s0022172400053778. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. MEIKLEJOHN G., KEMPE C. H., THALMAN W. G., LENNETTE E. H. Evaluation of monovalent influenza vaccines. II. Observations during an influenza a-prime epidemic. Am J Hyg. 1952 Jan;55(1):12–21. doi: 10.1093/oxfordjournals.aje.a119500. [DOI] [PubMed] [Google Scholar]
  16. PHILIP R. N., BELL J. A., DAVIS D. J., BEEM M. O., BEIGELMAN P. M., ENGLER J. I., MELLIN G. W., JOHNSON J. H., LERNER A. M. Epidemiologic studies on influenza in familial and general population groups, 1951-1956. II. Characteristics of occurrence. Am J Hyg. 1961 Mar;73:123–137. doi: 10.1093/oxfordjournals.aje.a120171. [DOI] [PubMed] [Google Scholar]
  17. Sugiura A., Yanagawa H., Enomoto C., Ueda M., Tobita K. A field trial for evaluation of the prophylactic effect of influenza vaccine containing inactivated A2-Hong Kong and B influenza viruses. J Infect Dis. 1970 Dec;122(6):472–478. doi: 10.1093/infdis/122.6.472. [DOI] [PubMed] [Google Scholar]

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