Abstract
Bacteriostatic activity was measured in 244 specimens of milk collected during 1977 throughout lactation of up to one year from 78 mothers; the activity varied from very good to fair and only seven were inactive. There was a wider range of activity than was found previously in milk from English mothers. Activity usually fell slowly during lactation but some of the Gambian mothers produced milk of very high activity, like that of colostrum into the second week of lactation, and two mothers did so at six and nine months; other mothers produced good-activity milk throughout lactation. The bacteriostatic activity varied little with the season but slight decreases from that expected were found after the high incidence of infant diarrhoea towards the end of the rainy season. The bacteriostatic activity of most of the milk tested could be prevented by iron salts but that of colostrum and some of the milks with high activity could not. Only these highly active colostra and milks were inhibitory in vitro when the inoculum was increased from 10(4) to 10(6) organisms per ml. These and less active milks were able to inhibit the smaller, standard inoculum for longer than 3 h with the addition of bicarbonate and extra iron-binding protein at the concentrations likely to be present in vivo. Both commensal and pathogenic E. coli were inhibited to a similar degree by these milks and there was no evidence of serotype specificity.
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- Bullen J. J., Rogers H. J., Leigh L. Iron-binding proteins in milk and resistance to Escherichia coli infection in infants. Br Med J. 1972 Jan 8;1(5792):69–75. doi: 10.1136/bmj.1.5792.69. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dolby J. M., Honour P. Bacteriostasis of Escherichia coli by milk. IV. The bacteriostatic antibody of human milk. J Hyg (Lond) 1979 Oct;83(2):255–265. doi: 10.1017/s0022172400026048. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dolby J. M., Stephens S., Honour P. Bacteriostasis of Escherichia coli by milk. II. Effect of bicarbonate and transferrin on the activity of infant feeds. J Hyg (Lond) 1977 Apr;78(2):235–242. doi: 10.1017/s0022172400056126. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dolby J. M., Stephens S., Royston J. P. The effect of freezing and pasteurizing bovine milk on its ability to protect neonatal guinea-pigs against colonization of the small intestine by Escherichia coli. Br J Exp Pathol. 1980 Feb;61(1):8–15. [PMC free article] [PubMed] [Google Scholar]
- Honour P., Dolby J. M. Bacteriostasis of Escherichia coli by milk. III. The activity and stability of early, transitional and mature human milk collected locally. J Hyg (Lond) 1979 Oct;83(2):243–254. doi: 10.1017/s0022172400026036. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rogers H. J., Synge C. Bacteriostatic effect of human milk on Escherichia coli: the role of IgA. Immunology. 1978 Jan;34(1):19–28. [PMC free article] [PubMed] [Google Scholar]
- Rowland M. G., Cole T. J., Tully M., Dolby J. M., Honour P. Bacteriostasis of Escherichia coli by milk. VI. The in-vitro bacteriostatic property of Gambian mothers' breast milk in relation to the in-vivo protection of their infants against diarrhoeal disease. J Hyg (Lond) 1980 Dec;85(3):405–413. doi: 10.1017/s0022172400063476. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stephens S., John M., Cooper J. E. The effect of in vitro antibacterial properties of bovine milk diets on the natural colonisation of newborn piglets with coliform bacteria. Res Vet Sci. 1979 Jan;26(1):21–24. [PubMed] [Google Scholar]