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. 1981 Dec;87(3):377–381. doi: 10.1017/s0022172400069618

Reducing the endotoxic activity of pertussis vaccine.

R M Bannatyne, R Cheung
PMCID: PMC2134129  PMID: 7310121

Abstract

Unadsorbed, regular production pertussis vaccine was treated with polymyxin B sulphate at concentrations of 25, 50 and 100 microgram/ml. The toxic activity of treated and untreated vaccines was compared using both the limulus amoebocyte lysate test and the mouse-weight-gain test. Protective efficacy was also assessed by the mouse protection test. No discernible effect on either toxicity or efficacy of the pertussis vaccine was observed. When the vaccine was treated with 5000 microgram/ml of polymyxin, endotoxic activity assessed by the limulus lysate test appeared to be abolished.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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