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. 1981 Dec;87(3):383–392. doi: 10.1017/s002217240006962x

Antibody responses after repeated influenza A virus immunizations among schoolchildren in Japan.

N Yamane, M Hiratsuka, J Arikawa, T Odagiri, N Ishida
PMCID: PMC2134136  PMID: 7310122

Abstract

Antibody responses to influenza virus immunizations were examined among junior high school students. The students received two doses of a commercial split-product vaccine containing influenza A H1N1 during a 2-year period following the first appearance of H1N1 virus in the winter of 1977-78. In haemagglutination-inhibition (HI) tests, the students who had been infected with H1N1 virus in 1977-78 showed a better response and wider cross-reactivity to the drift strain than the students who had not experienced earlier H1N1 influenza infection. Neuraminidase-inhibition (NAI) antibody titres after immunization depended upon a history of natural infection with H1N1 virus, since students not previously infected showed no significant NAI antibody rise after immunization.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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