Abstract
When a 1:5 mixture of trimethoprim (TMP) and sulphadiazine was fed to pigs intra-nasally infected with bordetella bronchiseptica, 10 mg/kg/day was shown to be highly effective in suppressing the organism. This dose level had little effect on numbers of TMP-resistant coliforms in faeces, but oral doses of 30 mg/kg/day eventually selected a resistant population. It is suggested that the proliferation of resistant coliforms would be minimized by administration of the lowest oral dose rates of antibacterial drugs compatible with efficacy.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Datta N., Hedges R. W. Trimethoprim resistance conferred by W plasmids in Enterobacteriaceae. J Gen Microbiol. 1972 Sep;72(2):349–355. doi: 10.1099/00221287-72-2-349. [DOI] [PubMed] [Google Scholar]
- Giles C. J., Smith I. M., Baskerville A. J., Oliphant J. Treatment of experimental Bordetella bronchiseptica infection in young pigs with potentiated sulphonamide in the drinking water. Vet Rec. 1981 Feb 14;108(7):136–139. doi: 10.1136/vr.108.7.136. [DOI] [PubMed] [Google Scholar]
- McCandlish I. A., Thompson H. Canine bordetellosis: chemotherapy using a sulphadiazine-trimethoprim combination. Vet Rec. 1979 Jul 21;105(3):51–54. doi: 10.1136/vr.105.3.51. [DOI] [PubMed] [Google Scholar]
- Rollins L. D., Gaines S. A., Pocurull D. W., Mercer H. D. Animal model for determining the no-effect level of an antimicrobial drug on drug resistance in the lactose-fermenting enteric flora. Antimicrob Agents Chemother. 1975 May;7(5):661–665. doi: 10.1128/aac.7.5.661. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Smith H. W., Lovell M. A. Escherichia coli resistant to tetracyclines and to other antibiotics in the faeces of U.K. chickens and pigs in 1980. J Hyg (Lond) 1981 Dec;87(3):477–483. doi: 10.1017/s0022172400069722. [DOI] [PMC free article] [PubMed] [Google Scholar]