Abstract
During the ten-year period 1971-80 isolates of meningococci from 85 cases of meningococcal disease (MD) in South Australia, from 66 children, 6 adolescents and 13 adults, were examined. These comprised 69 cases of meningitis and 16 cases of bacteraemia without meningitis. Thirty-three (39%) of all cases of MD occurred in children less than 1 year of age, the median age was 19 months. Serogroup B accounted for 61 (72%) cases of MD, group A seven (8%), group C seven (8%), group W135 five (6%), group Y three (4%) and group X one (1%); in addition there was a single case of Neisseria lactamica infection. The annual prevalence of MD in South Australia for the period was 11 cases per 100000 for children under the age of 2 years and 0.7 cases per 100000 overall. The prevalence was highest in winter (45% cases) and spring (26%) and lowest in summer (13%). The overall mortality rate was 8%. Four of the 21 infants under the age of 6 months died (mortality rate 19%) whereas none of the 32 children aged from 6 months to 14 years died (P = 0.02). Amongst the survivors, three children had deafness, which was bilateral and severe in two.
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- Artenstein M. S., Gold R., Zimmerly J. G., Wyle F. A., Schneider H., Harkins C. Prevention of meningococcal disease by group C polysaccharide vaccine. N Engl J Med. 1970 Feb 19;282(8):417–420. doi: 10.1056/NEJM197002192820803. [DOI] [PubMed] [Google Scholar]
- Feldman H. A. Some recollections of the meningococcal diseases. The first Harry F. Dowling lecture. JAMA. 1972 May 22;220(8):1107–1112. [PubMed] [Google Scholar]
- Gotschlich E. C., Goldschneider I., Artenstein M. S. Human immunity to the meningococcus. IV. Immunogenicity of group A and group C meningococcal polysaccharides in human volunteers. J Exp Med. 1969 Jun 1;129(6):1367–1384. doi: 10.1084/jem.129.6.1367. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Greenwood B. M., Bradley A. K., Cleland P. G., Haggie M. H., Hassan-King M., Lewis L. S., Macfarlane J. T., Taqi A., Whittle H. C., Bradley-Moore A. M. An epidemic of meningococcal infection at Zaria, Northern Nigeria. 1. General epidemiological features. Trans R Soc Trop Med Hyg. 1979;73(5):557–562. doi: 10.1016/0035-9203(79)90052-x. [DOI] [PubMed] [Google Scholar]
- Hansman D. Meningitis caused by Neisseria lactamica. N Engl J Med. 1978 Aug 31;299(9):491–491. [PubMed] [Google Scholar]
- Peltola H., Jónsdóttir K., Lystad A., Sievers C. J., Kallings I. Meningococcal disease in Scandinavia. Br Med J (Clin Res Ed) 1982 May 29;284(6329):1618–1621. doi: 10.1136/bmj.284.6329.1618. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Peltola H., Mäkelä H., Käyhty H., Jousimies H., Herva E., Hällström K., Sivonen A., Renkonen O. V., Pettay O., Karanko V. Clinical efficacy of meningococcus group A capsular polysaccharide vaccine in children three months to five years of age. N Engl J Med. 1977 Sep 29;297(13):686–691. doi: 10.1056/NEJM197709292971302. [DOI] [PubMed] [Google Scholar]
- Souza de Morais J., Munford R. S., Risi J. B., Antezana E., Feldman R. A. Epidemic disease due to serogroup C Neisseria meningitidis in Saõ Paulo, Brazil. J Infect Dis. 1974 May;129(5):568–571. doi: 10.1093/infdis/129.5.568. [DOI] [PubMed] [Google Scholar]