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. 1982 Dec;89(3):383–388. doi: 10.1017/s0022172400070959

A poxvirus antigen associated with pathogenicity for rabbits.

C J Rondle, K R Dumbell
PMCID: PMC2134225  PMID: 6296225

Abstract

White pock variants of cowpox virus give papular lesions on intradermal inoculation of rabbits, without the necrosis and haemorrhage that are produced by wild type cowpox viruses. Rondle & Dumbell (1962) have shown that white pock variants of cowpox virus fail to produce a specific, precipitating antigen which they called 'd' substance. In this paper it is shown that 'd' is demonstrable in soluble antigen preparations of rabbitpox virus and of neurovirulent strains of vaccinia virus but not in soluble antigens of variola viruses. Two series of recombinant viruses prepared by Dumbell & Bedson (1964) from variola and cowpox and from variola and rabbitpox viruses were tested for the production of 'd' substance. These results were compared with the previously recorded effects of these recombinants when inoculated intradermally in rabbits. It is concluded that functional genes determining the production of 'd' and of rabbit skin pathogenicity are closely linked on the pox virus genome, but that there is insufficient evidence to say that the two functions are interdependent.

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Selected References

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  1. Amano H., Ueda Y., Tagaya I. Orthopoxvirus strains defective in surface antigen induction. J Gen Virol. 1979 Jul;44(1):265–269. doi: 10.1099/0022-1317-44-1-265. [DOI] [PubMed] [Google Scholar]
  2. Archard L. C., Mackett M. Restriction endonuclease analysis of red cowpox virus and its white pock variant. J Gen Virol. 1979 Oct;45(1):51–63. doi: 10.1099/0022-1317-45-1-51. [DOI] [PubMed] [Google Scholar]
  3. BEDSON H. S., DUMBELL K. R. HYBRIDS DERIVED FROM THE VIRUSES OF ALASTRIM AND RABBIT POX. J Hyg (Lond) 1964 Jun;62:141–146. doi: 10.1017/s0022172400039875. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. BEDSON H. S., DUMBELL K. R. HYBRIDS DERIVED FROM THE VIRUSES OF VARIOLA MAJOR AND COWPOX. J Hyg (Lond) 1964 Jun;62:147–158. doi: 10.1017/s0022172400039887. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. BEDSON H. S., DUMBELL K. R. The effect of temperature on the growth of pox viruses in the chick embryo. J Hyg (Lond) 1961 Dec;59:457–469. doi: 10.1017/s0022172400039152. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Baxby D., Rondle C. J. The inhibition of growth of vaccinia and cowpox viruses in RK 13 cells. J Hyg (Lond) 1968 Jun;66(2):191–205. doi: 10.1017/s0022172400041073. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. DOWNIE A. W., HADDOCK D. W. A variant of cowpox virus. Lancet. 1952 May 24;1(6717):1049–1050. doi: 10.1016/s0140-6736(52)90698-3. [DOI] [PubMed] [Google Scholar]
  8. DUMBELL K. R., BEDSON H. S. THE USE OF CEILING TEMPERATURE AND REACTIVATION IN THE ISOLATION OF POX VIRUS HYBRIDS. J Hyg (Lond) 1964 Jun;62:133–140. doi: 10.1017/s0022172400039863. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. FENNER F. The biological characters of several strains of vaccinia, cowpox and rabbitpox viruses. Virology. 1958 Jun;5(3):502–529. doi: 10.1016/0042-6822(58)90042-4. [DOI] [PubMed] [Google Scholar]
  10. Mackett M., Archard L. C. Conservation and variation in Orthopoxvirus genome structure. J Gen Virol. 1979 Dec;45(3):683–701. doi: 10.1099/0022-1317-45-3-683. [DOI] [PubMed] [Google Scholar]
  11. RONDLE C. J., DUMBELL K. R. Antigens of cowpox virus. J Hyg (Lond) 1962 Mar;60:41–49. doi: 10.1017/s0022172400039292. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. VAN TONGEREN H. A. E. Spontaneous mutation of cowpox-virus by means of egg-passage. Arch Gesamte Virusforsch. 1952;5(1):35–52. doi: 10.1007/BF01245138. [DOI] [PubMed] [Google Scholar]

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