Abstract
It was found that 26 of 127 infants with chlamydial conjunctivitis had previously received chloramphenicol eye drops. This treatment had delayed the onset and reduced the degree of oedema, congestion and discharge compared with infected infants with no 'first-line' chemotherapy, but eye swabs remained positive in 22 (85%) of the chloramphenicol treated infants. The problems of designing laboratory tests which might accurately forecast the clinical value, or lack of value of antibiotics in chlamydial infections were investigated. The minimum inhibitory concentration (MIC) of chloramphenicol, against Chlamydia trachomatis in McCoy cell cultures varied widely according to the antibiotic preparation used, the timing and duration of its exhibition in relation to the single step growth cycle of C. trachomatis, and, in particular, the method of examination of infected tissue cultures for residual chlamydial growth after incubation with chloramphenicol.
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- Bushell A. C., Hobson D. Effect of cortisol on the growth of Chlamydia trachomatis in McCoy cells. Infect Immun. 1978 Sep;21(3):946–953. doi: 10.1128/iai.21.3.946-953.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Davies J. A., Rees E., Hobson D., Karayiannis P. Isolation of Chlamydia trachomatis from Bartholin's ducts. Br J Vener Dis. 1978 Dec;54(6):409–413. doi: 10.1136/sti.54.6.409. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Johnson F. W., Hobson D. The effect of penicillin on genital strains of Chlamydia trachomatis in tissue culture. J Antimicrob Chemother. 1977 Jan;3(1):49–56. doi: 10.1093/jac/3.1.49. [DOI] [PubMed] [Google Scholar]
- Karayiannis P., Hobson D. Amino acid requirements of a Chlamydia trachomatis genital strain in McCoy cell cultures. J Clin Microbiol. 1981 Mar;13(3):427–432. doi: 10.1128/jcm.13.3.427-432.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Karayiannis P., Hobson D. The role of calf serum in the growth of Chlamydia trachomatis in McCoy cell cultures. J Gen Microbiol. 1981 Jan;122(1):47–54. doi: 10.1099/00221287-122-1-47. [DOI] [PubMed] [Google Scholar]
- Kuo C. C., Wang S. P., Grayston J. T. Antimicrobial activity of several antibiotics and a sulfonamide against Chlamydia trachomatis organisms in cell culture. Antimicrob Agents Chemother. 1977 Jul;12(1):80–83. doi: 10.1128/aac.12.1.80. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rees E., Tait I. A., Hobson D., Byng R. E., Johnson F. W. Neonatal conjunctivitis caused by Neisseria gonorrhoeae and Chlamydia trachomatis. Br J Vener Dis. 1977 Jun;53(3):173–179. doi: 10.1136/sti.53.3.173. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rees E., Tait I. A., Hobson D., Karayiannis P., Lee N. Persistence of chlamydial infection after treatment for neonatal conjunctivitis. Arch Dis Child. 1981 Mar;56(3):193–198. doi: 10.1136/adc.56.3.193. [DOI] [PMC free article] [PubMed] [Google Scholar]