Abstract
Eight sera from 125 cases of infectious mononucleosis (IM) were reactive for rubella-specific IgM in an M-antibody capture radioimmunoassay. The reactivity of individual sera varied depending upon the source of the rubella antigen used in the assay. One serum gave strongly positive results with some rubella haemagglutinating antigens but negative results with others and may have contained an IgM antibody which was capable of distinguishing between strains of rubella virus. If the diagnosis of rubella is based solely on detection in solid-phase immunoassay of rubella-specific IgM, IM should be excluded.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Carter R. L. Antibody formation in infectious mononucleosis. II. Other 19S antibodies and false-positive serology. Br J Haematol. 1966 May;12(3):268–275. doi: 10.1111/j.1365-2141.1966.tb05633.x. [DOI] [PubMed] [Google Scholar]
- Cradock-Watson J. E., Bourne M. S., Vandervelde E. M. IgG, IgA and IgM responses in acute rubella determined by the immunofluorescent technique. J Hyg (Lond) 1972 Sep;70(3):473–485. doi: 10.1017/s0022172400063063. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Epstein M. A., Achong B. G. Pathogenesis of infectious mononucleosis. Lancet. 1977 Dec 17;2(8051):1270–1273. doi: 10.1016/s0140-6736(77)92673-3. [DOI] [PubMed] [Google Scholar]
- Kurtz J. B., Mortimer P. P., Mortimer P. R., Morgan-Capner P., Shafi M. S., White G. B. Rubella antibody measured by radial haemolysis. Characteristics and performance of a simple screening method for use in diagnostic laboratories. J Hyg (Lond) 1980 Apr;84(2):213–222. doi: 10.1017/s0022172400026711. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morgan-Capner P., Davies E., Pattison J. R. Rubella-specific IgM detection using Sephacryl S-300 gel filtration. J Clin Pathol. 1980 Nov;33(11):1082–1085. doi: 10.1136/jcp.33.11.1082. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mortimer P. P., Tedder R. S., Hamblig M. H., Shafi M. S., Burkhardt F., Schilt U. Antibody capture radioimmunoassay for anti-rubella IgM. J Hyg (Lond) 1981 Apr;86(2):139–153. doi: 10.1017/s0022172400068856. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pattison J. R., Mace J. E. The detection of specific IgM antibodies following infection with rubella virus. J Clin Pathol. 1975 May;28(5):377–382. doi: 10.1136/jcp.28.5.377. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tedder R. S., Yao J. L., Anderson M. J. The production of monoclonal antibodies to rubella haemagglutinin and their use in antibody-capture assays for rubella-specific IgM. J Hyg (Lond) 1982 Apr;88(2):335–350. doi: 10.1017/s0022172400070182. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Urqhuart G. E., Carson H. G. Laboratory policy for rubella screening. Lancet. 1982 Nov 27;2(8309):1226–1226. doi: 10.1016/s0140-6736(82)91255-7. [DOI] [PubMed] [Google Scholar]