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. 1986 Oct;168(1):160–166. doi: 10.1128/jb.168.1.160-166.1986

cmp, a cis-acting plasmid locus that increases interaction between replication origin and initiator protein.

M L Gennaro, R P Novick
PMCID: PMC213432  PMID: 3759903

Abstract

pT181, a 4.4-kilobase multicopy plasmid of Staphylococcus aureus, encodes a trans-acting initiator protein, RepC, which was rate limiting for replication. Deletions in a 500-base-pair region of the plasmid external to the minimal replicon decreased the ability of the plasmid to compete with a coexisting incompatible plasmid. These deletions, which define a region called cmp (for competition), appeared to affect the interaction of RepC and the plasmid origin of replication. However, in the homoplasmid state the deletions affected neither copy number nor plasmid stability. The Cmp phenotype is orientation independent, and cmp defects could not be complemented in trans.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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