Table 1.

Biodistribution of ¹²⁵I- and ¹¹¹In-CHX-A″-DTPA-Labeled mAb 806 in A431 Xenografted BALB/c Nude Mice^*.

Time† (Hours)	n‡	% ID/g§ in A431 Tumor (Mean ± SD)		% ID/g in Blood (Mean ± SD)
		111In	125I	111In	125I
4	4	21.8 ± 6.1	13.7 ± 3.3	30.9 ± 1.9	29.8 ± 1.7
24	4	36.4 ± 10.0	9.9 ± 3.5	19.3 ± 2.3	18.6 ± 2.2
48	4	44.9 ± 11.4	7.2 ± 2.3	12.6 ± 1.7	12.5 ± 1.7
72	4	36.6 ± 8.2	4.5 ± 1.2	13.2 ± 1.9	10.7 ± 1.2
168	4	23.6 ± 6.3	2.5 ± 0.9	5.2 ± 1.7	4.7 ± 1.6

^*Mice bearing A431 tumors received tail vein injections containing 5 µCi of both ¹²⁵I- and ¹¹¹In-CHX-A±-DPTA-labeled mAb 806 (total, 10 µg of antibody; 10 µCi) on day 0. Groups of four mice were sacrificed at the indicated times. The blood was collected, tumors removed, blotted dry, and weighed. Radioactivity was measured.

^†Time in hours after injection of antibody.

^‡Number of mice per time point.

^§% ID/g was calculated. Data are presented as mean ± SD.