Abstract
A substance is regularly present in saline extracts of the Brown-Pearce rabbit carcinoma growth which is capable of fixing complement specifically in mixture with the sera of certain rabbits bearing the tumor or in which this has recently retrogressed, as the foregoing experiments have shown. The substance was not demonstrable in extracts of the normal tissues, virus papillomas, or uterine cancers of rabbits, nor in extracts of rabbit tissues infected with certain viruses (vaccine virus, Virus III, fibroma virus). The sera of normal rabbits, of those immune to a variety of infectious diseases, including syphilis, vaccinia, fibromatosis, and Virus III, and of others with uterine cancers or virus-induced papillomas, failed to fix complement specifically in mixture with extracts containing the antigen of the Brown-Pearce tumor. The significance of the findings will be discussed in the succeeding paper, after consideration has been given to some of the properties of the serologically active material derived from the Brown-Pearce tumor.
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Selected References
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- Brown W. H., Pearce L. STUDIES BASED ON A MALIGNANT TUMOR OF THE RABBIT : III. INTRATESTICULAR TRANSPLANTATION AND CLINICAL COURSE OF THE DISEASE. J Exp Med. 1923 May 31;37(6):799–810. doi: 10.1084/jem.37.6.799. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Greene H. S., Saxton J. A. UTERINE ADENOMATA IN THE RABBIT : I. CLINICAL HISTORY, PATHOLOGY AND PRELIMINARY TRANSPLANTATION EXPERIMENTS. J Exp Med. 1938 Apr 30;67(5):691–708. doi: 10.1084/jem.67.5.691. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kidd J. G. IMMUNOLOGICAL REACTIONS WITH A VIRUS CAUSING PAPILLOMAS IN RABBITS : III. ANTIGENICITY AND PATHOGENICITY OF EXTRACTS OF THE GROWTHS OF WILD AND DOMESTIC SPECIES: GENERAL DISCUSSION. J Exp Med. 1938 Oct 31;68(5):737–759. doi: 10.1084/jem.68.5.737. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pearce L., Brown W. H. STUDIES BASED ON A MALIGNANT TUMOR OF THE RABBIT : IV. THE RESULTS OF MISCELLANEOUS METHODS OF TRANSPLANTATION, WITH A DISCUSSION OF FACTORS INFLUENCING TRANSPLANTATION IN GENERAL. J Exp Med. 1923 May 31;37(6):811–828. doi: 10.1084/jem.37.6.811. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rivers T. M., Tillett W. S. FURTHER OBSERVATIONS ON THE PHENOMENA ENCOUNTERED IN ATTEMPTING TO TRANSMIT VARICELLA TO RABBITS. J Exp Med. 1924 May 31;39(6):777–802. doi: 10.1084/jem.39.6.777. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rous P., Murphy J. B. ON IMMUNITY TO TRANSPLANTABLE CHICKEN TUMORS. J Exp Med. 1914 Oct 1;20(4):419–432. doi: 10.1084/jem.20.4.419. [DOI] [PMC free article] [PubMed] [Google Scholar]